ID Q4QFI5_LEIMA Unreviewed; 311 AA.
AC Q4QFI5;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Putative glutathione-S-transferase/glutaredoxin {ECO:0000313|EMBL:CAJ03223.1};
GN ORFNames=LMJF_14_1480 {ECO:0000313|EMBL:CAJ03223.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ03223.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ03223.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ03223.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796410; CAJ03223.1; -; Genomic_DNA.
DR RefSeq; XP_001687749.1; XM_001687697.1.
DR AlphaFoldDB; Q4QFI5; -.
DR STRING; 5664.Q4QFI5; -.
DR EnsemblProtists; CAJ03223; CAJ03223; LMJF_14_1480.
DR GeneID; 5650353; -.
DR KEGG; lma:LMJF_14_1480; -.
DR VEuPathDB; TriTrypDB:LmjF.14.1480; -.
DR VEuPathDB; TriTrypDB:LMJFC_140023100; -.
DR VEuPathDB; TriTrypDB:LMJLV39_140022700; -.
DR VEuPathDB; TriTrypDB:LMJSD75_140022400; -.
DR eggNOG; KOG3029; Eukaryota.
DR HOGENOM; CLU_011226_0_1_1; -.
DR InParanoid; Q4QFI5; -.
DR OMA; DYCLTEG; -.
DR Proteomes; UP000000542; Chromosome 14.
DR GO; GO:0020023; C:kinetoplast; ISO:GeneDB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; ISO:GeneDB.
DR GO; GO:0050220; F:prostaglandin-E synthase activity; IEA:InterPro.
DR CDD; cd03040; GST_N_mPGES2; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR034334; PGES2.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12782; MICROSOMAL PROSTAGLANDIN E SYNTHASE-2; 1.
DR PANTHER; PTHR12782:SF9; PROSTAGLANDIN E SYNTHASE 2; 1.
DR Pfam; PF13417; GST_N_3; 1.
DR SFLD; SFLDG01182; Prostaglandin_E_synthase_like; 1.
DR SFLD; SFLDG01203; Prostaglandin_E_synthase_like1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..144
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13417"
SQ SEQUENCE 311 AA; 35413 MW; E3ACA317C1840288 CRC64;
MFGRGTFSRK VLVGTTVAGF VGVGAGYTMY QRRLRDNRSV TAEAFNAMQD ATKLDEAFKK
LCDPKEHPLI QFYRYTTCPW CGTVKAFLDY NKIPHECVEV EPMFKTELAE SLYKKVPQLR
FESEAGARSY LVDSQIIVDT LSEKMGLGGQ LKDEDVNKWR TWARSSLVRF VTLEFNHSLP
AAWAGYSYID SCDTIPYANK LFLKVIGAPV MYLVAMMVTK PRLVKAGLMK PDDDPKQRLH
DEVNRFTAEA LVDPKSKKPR TFHGGRKPDL VDLDTYGVLQ SVRNHRIYNE MVTETQIGPW
LEAMDRLMGK V
//
