ID Q4QHI1_LEIMA Unreviewed; 595 AA.
AC Q4QHI1;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=Putative folate/biopterin transporter {ECO:0000313|EMBL:CAJ02519.1};
GN ORFNames=LMJF_10_0370 {ECO:0000313|EMBL:CAJ02519.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02519.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ02519.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ02519.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
CC biopterin transporter (TC 2.A.71) family.
CC {ECO:0000256|ARBA:ARBA00007015}.
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DR EMBL; FR796406; CAJ02519.1; -; Genomic_DNA.
DR RefSeq; XP_001681367.1; XM_001681315.1.
DR AlphaFoldDB; Q4QHI1; -.
DR STRING; 5664.Q4QHI1; -.
DR EnsemblProtists; CAJ02519; CAJ02519; LMJF_10_0370.
DR GeneID; 5649636; -.
DR KEGG; lma:LMJF_10_0370; -.
DR VEuPathDB; TriTrypDB:LmjF.10.0370; -.
DR VEuPathDB; TriTrypDB:LMJFC_100010200; -.
DR VEuPathDB; TriTrypDB:LMJLV39_100008900; -.
DR VEuPathDB; TriTrypDB:LMJSD75_100009300; -.
DR HOGENOM; CLU_027837_0_0_1; -.
DR InParanoid; Q4QHI1; -.
DR OMA; YLNSNEC; -.
DR Proteomes; UP000000542; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR039309; BT1.
DR InterPro; IPR004324; FBT.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00788; fbt; 1.
DR PANTHER; PTHR31585; FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC; 1.
DR PANTHER; PTHR31585:SF51; TRANSPORTER, PUTATIVE-RELATED; 1.
DR Pfam; PF03092; BT1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 189..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 595 AA; 65027 MW; 18D8858C1FE34D38 CRC64;
MMIDRYGISV PRYQRLSSLS SMGWSIKAFT AMLCDGFAFL GYTKRWYMFI SCVGGGAFAL
IYGLLPAKEA SADVACAFIF LSTWGKANVD ILSEGHYSRL MRENPKPGPS MVSWIWFWIM
VGAIIATVMN GPLADAGKPQ ISIFVSAALQ AITCVFYLFN WYGEKKNRVL RSEDALFILE
ETRKERERLG LEGVNDGTAG AQHGGAAKGK KSPQHSHSDE DVEGAVRDAL NDGQRDNGEL
VQDVYDDAYD DGEGVAEGDV YYGKPPVPCL FGLFEANTEV ISKNWKIFVY SVVMTCAVIT
MLCANMLADT LGLLIACVVV STICCATSFW ALPLVIAKAN VFAYLQMAVY IRASSPLYAF
YLNSNECPGN LPNFTYTFYG TVAGVIGNFA GLVGVTLFNF LFAKHNYQVT FIATTIMQVM
AALFDIIIVK RWNLHIGIPD HAMYIWGDAV VAQIVYMLGF MPLVVMLSRL CPRGSESVVY
ALMAGFANLG QTTAASLGAI IMEYGWPVFS DNDPCNYDNL PLLLFVTSVC TPLLVIPLSY
LLPMARICDD IDIDGKVVRQ KADEMCVKVV AAAEENTSEH SAEASAAAAA PKDHA
//
