ID Q4QHJ7_LEIMA Unreviewed; 473 AA.
AC Q4QHJ7;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Nucleolar protein 56 {ECO:0000256|ARBA:ARBA00040742};
GN ORFNames=LMJF_10_0210 {ECO:0000313|EMBL:CAJ02424.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02424.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ02424.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ02424.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the NOP5/NOP56 family.
CC {ECO:0000256|ARBA:ARBA00009211}.
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DR EMBL; FR796406; CAJ02424.1; -; Genomic_DNA.
DR RefSeq; XP_001681351.1; XM_001681299.1.
DR AlphaFoldDB; Q4QHJ7; -.
DR SMR; Q4QHJ7; -.
DR STRING; 5664.Q4QHJ7; -.
DR EnsemblProtists; CAJ02424; CAJ02424; LMJF_10_0210.
DR GeneID; 5649619; -.
DR KEGG; lma:LMJF_10_0210; -.
DR VEuPathDB; TriTrypDB:LmjF.10.0210; -.
DR VEuPathDB; TriTrypDB:LMJFC_100008200; -.
DR VEuPathDB; TriTrypDB:LMJLV39_100007000; -.
DR VEuPathDB; TriTrypDB:LMJSD75_100007100; -.
DR eggNOG; KOG2573; Eukaryota.
DR HOGENOM; CLU_015495_4_0_1; -.
DR InParanoid; Q4QHJ7; -.
DR OMA; DNYMFAK; -.
DR Proteomes; UP000000542; Chromosome 10.
DR GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; ISO:GeneDB.
DR GO; GO:0005654; C:nucleoplasm; ISO:GeneDB.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.4070; -; 1.
DR Gene3D; 1.10.246.90; Nop domain; 1.
DR InterPro; IPR045056; Nop56/Nop58.
DR InterPro; IPR012974; NOP58/56_N.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR PANTHER; PTHR10894; NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58; 1.
DR PANTHER; PTHR10894:SF0; NUCLEOLAR PROTEIN 56; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF08156; NOP5NT; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; Nop domain; 1.
DR PROSITE; PS51358; NOP; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 302..421
FT /note="Nop"
FT /evidence="ECO:0000259|PROSITE:PS51358"
FT REGION 447..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 52686 MW; E78CFF8667F28F54 CRC64;
MSRTLYTLYE APTGYAIFKV RTTEEIGAED VALQKELQRF STFSPWVKLV SFAPFESPEN
ALEDAVCISE NLMSTFLNNF LTAAFAKKVA KNEANWELGV QDPKLGSAIH DELNIPVLCN
ETVAEISRCI RLHAEKLLPE HNEGDVPRAQ CGLGHAFSRN KVKFNVHRSD NMIIQASALM
EHMDKGVNLL GMRVKEWYGW HFPELAKEVP EPLKYANVAL LIGNRNSLEE APEEDVKAQL
GDILEGDEAL AARVYEKAVT SMGGDMAEVD WDCIRTFAKR VASLGQYRVA LAQYLVDKMM
LVAPNLTQLM GQTIGAKLIS KAGSLTNLAK SPASTIQILG AEKALFRALK KKKGNTPKYG
LIFHSSFIQR ASKENRGKIS RYLANKAALA CRIDCFMDAP PTVFGEKLRE QVEARLNFFD
TGNKPPSNKA AMAEALEQYQ RILRKRNRKQ ANEDTEETPK KKSRKVVAAS ESG
//
