ID Q4QRD0_DANRE Unreviewed; 591 AA.
AC Q4QRD0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Syntaxin-binding protein 1 {ECO:0000256|ARBA:ARBA00040519};
DE AltName: Full=Protein unc-18 homolog 1 {ECO:0000256|ARBA:ARBA00042596};
DE AltName: Full=Protein unc-18 homolog A {ECO:0000256|ARBA:ARBA00042593};
GN Name=stxbp1a {ECO:0000313|RefSeq:NP_001020353.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050626-106};
GN Synonyms=stxbp1 {ECO:0000313|RefSeq:NP_001020353.1}, wu:fj36d12
GN {ECO:0000313|RefSeq:NP_001020353.1}, wu:fj43h10
GN {ECO:0000313|RefSeq:NP_001020353.1}, zgc:114171
GN {ECO:0000313|RefSeq:NP_001020353.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH97221.1};
RN [1] {ECO:0000313|EMBL:AAH97221.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larvae {ECO:0000313|EMBL:AAH97221.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001020353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20102740; DOI=10.1016/j.matbio.2010.01.006;
RA Hoffman G.G., Branam A.M., Huang G., Pelegri F., Cole W.G., Wenstrup R.M.,
RA Greenspan D.S.;
RT "Characterization of the six zebrafish clade B fibrillar procollagen genes,
RT with evidence for evolutionarily conserved alternative splicing within the
RT pro-alpha1(V) C-propeptide.";
RL Matrix Biol. 29:261-275(2010).
RN [3] {ECO:0000313|RefSeq:NP_001020353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23499359;
RA Veerkamp J., Rudolph F., Cseresnyes Z., Priller F., Otten C., Renz M.,
RA Schaefer L., Abdelilah-Seyfried S.;
RT "Unilateral dampening of bmp activity by nodal generates cardiac left-right
RT asymmetry.";
RL Dev. Cell 24:660-667(2013).
RN [4] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001020353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_001020353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25142379; DOI=10.1007/s12015-014-9523-2;
RA Liu R., Li M., Li Z., Hong N., Xu H., Hong Y.;
RT "Medaka Oct4 is essential for pluripotency in blastula formation and ES
RT cell derivation.";
RL Stem. Cell. Rev. Rep. 11:11-23(2015).
RN [7] {ECO:0000313|RefSeq:NP_001020353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26818140;
RA Coppola U., Annona G., D'Aniello S., Ristoratore F.;
RT "Rab32 and Rab38 genes in chordate pigmentation: an evolutionary
RT perspective.";
RL BMC Evol. Biol. 16:26-26(2016).
RN [8] {ECO:0000313|RefSeq:NP_001020353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [9] {ECO:0000313|RefSeq:NP_001020353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26963117;
RA Grone B.P., Marchese M., Hamling K.R., Kumar M.G., Krasniak C.S., Sicca F.,
RA Santorelli F.M., Patel M., Baraban S.C.;
RT "Epilepsy, Behavioral Abnormalities, and Physiological Comorbidities in
RT Syntaxin-Binding Protein 1 (STXBP1) Mutant Zebrafish.";
RL PLoS ONE 11:e0151148-e0151148(2016).
RN [10] {ECO:0000313|RefSeq:NP_001020353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28679150;
RA Hu H., Zhang Y., Shi Y., Feng L., Duan J., Sun Z.;
RT "Microarray-based bioinformatics analysis of the combined effects of SiNPs
RT and PbAc on cardiovascular system in zebrafish.";
RL Chemosphere 184:1298-1309(2017).
RN [11] {ECO:0000313|RefSeq:NP_001020353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [12] {ECO:0000313|RefSeq:NP_001020353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28711009;
RA Hu H., Shi Y., Zhang Y., Wu J., Asweto C.O., Feng L., Yang X., Duan J.,
RA Sun Z.;
RT "Comprehensive gene and microRNA expression profiling on cardiovascular
RT system in zebrafish co-exposured of SiNPs and MeHg.";
RL Sci. Total Environ. 607-608:795-805(2017).
RN [13] {ECO:0000313|RefSeq:NP_001020353.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family.
CC {ECO:0000256|ARBA:ARBA00009884}.
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DR EMBL; BC097221; AAH97221.1; -; mRNA.
DR RefSeq; NP_001020353.1; NM_001025182.1.
DR GeneID; 574003; -.
DR KEGG; dre:574003; -.
DR AGR; ZFIN:ZDB-GENE-050626-106; -.
DR CTD; 574003; -.
DR ZFIN; ZDB-GENE-050626-106; stxbp1a.
DR OrthoDB; 4609640at2759; -.
DR PhylomeDB; Q4QRD0; -.
DR Proteomes; UP000000437; Chromosome 21.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR GO; GO:0017075; F:syntaxin-1 binding; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 1.25.40.60; -; 1.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR PANTHER; PTHR11679:SF35; SYNTAXIN-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR11679; VESICLE PROTEIN SORTING-ASSOCIATED; 1.
DR Pfam; PF00995; Sec1; 1.
DR PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR SUPFAM; SSF56815; Sec1/munc18-like (SM) proteins; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q4QRD0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
SQ SEQUENCE 591 AA; 67129 MW; A253A9EF7F1D3727 CRC64;
MAPIGLKAVV GEKIMNDVIK KVKKKGEWKA LIVDQLSMRM LSSCCKMTDI MTEGITIVED
IMKRREPLPS LEAIYLITPT DKSVQTLIND FKDPHSAKYK GAHVFFTDSC PDPLFNEVVK
SRASKTIKTL NEINIAFLPY ESQVFSLDNP DAFQSFYSPH KTQLKNPVME RLAEQLATLC
ATLKEYPAVR YRGEYKDNAT LAQLLQDKLD AYKADDPTMG EGPDKARSQL IILDRGFDPV
SPVLHELTFQ AMAYDLLPIE NDVYKYDTSG IGDSREKEVL LHEDDDLWVA LRHKHIAEVS
QEVTRSLKEF SASKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLQL AEDCMKHYQG
TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVT TYDKIRIILL YIFLKNGITE
ENLNKLIQYA QIPPEDSEII TNMAHLGVPI ITDSTLRRGK RMDRKERVSE QTYQLSRWTP
LIKDIMEDAI DDKLDTKHYP YISTRSSSSF STSAVSARYG HWHKNKTPGE YRTGPRIMVF
IIGGASFSEM RCAYEVTQAN GKWEAIVGST HVGGPTQLLD ALKAMNKPDE E
//
