ID Q4QRG7_DANRE Unreviewed; 434 AA.
AC Q4QRG7;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=RNA-binding motif protein, X-linked 2 {ECO:0000313|EMBL:AAH96985.1, ECO:0000313|RefSeq:NP_001020337.1};
GN Name=rbmx2 {ECO:0000313|EMBL:AAH96985.1,
GN ECO:0000313|RefSeq:NP_001020337.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050626-88};
GN Synonyms=im:7141316 {ECO:0000313|RefSeq:NP_001020337.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH96985.1};
RN [1] {ECO:0000313|EMBL:AAH96985.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH96985.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:NP_001020337.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29969449;
RA Fernandez J.P., Moreno-Mateos M.A., Gohr A., Miao L., Chan S.H., Irimia M.,
RA Giraldez A.J.;
RT "RES complex is associated with intron definition and required for
RT zebrafish early embryogenesis.";
RL PLoS Genet. 14:e1007473-e1007473(2018).
RN [4] {ECO:0000313|RefSeq:NP_001020337.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30755680;
RA Huang L., Urasaki A., Inagaki N.;
RT "Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in
RT the zebrafish brain.";
RL Sci. Rep. 9:1799-1799(2019).
RN [5] {ECO:0000313|RefSeq:NP_001020337.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC096985; AAH96985.1; -; mRNA.
DR RefSeq; NP_001020337.1; NM_001025166.1.
DR GeneID; 553240; -.
DR KEGG; dre:553240; -.
DR AGR; ZFIN:ZDB-GENE-050626-88; -.
DR CTD; 51634; -.
DR ZFIN; ZDB-GENE-050626-88; rbmx2.
DR OrthoDB; 168812at2759; -.
DR Proteomes; UP000000437; Alternate scaffold 21.
DR Proteomes; UP000000437; Chromosome 21.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IMP:ZFIN.
DR CDD; cd12411; RRM_ist3_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR045844; RRM_Ist3-like.
DR PANTHER; PTHR45880; RNA-BINDING MOTIF PROTEIN, X-LINKED 2; 1.
DR PANTHER; PTHR45880:SF1; RNA-BINDING MOTIF PROTEIN, X-LINKED 2; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 36..114
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 135..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..175
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 51734 MW; E85E7C32D1C066D1 CRC64;
MNPLTKVKLI NELNEREAQL GIKETVSWHS VYKNSAWVFI GGFPYELTEG DIICVFSQYG
EIANINLVRD KKTGKSKGFC FLCYEDQRST ILAVDNFNGI KIKGRTIRVD HVANYRPPKD
TDDIDDITKQ LREEGCAPKP VSSSEEESAE EYAVPVKKPK KDKKEKKKKK KEKKEKKKAL
KEEKREGRSE SSASSPVRVK KEKEDVAYEK YSVKGPAANR RDRADEQEQL KEKEREREEG
KKTDRRHAET QQRERDREGE REGDKERERD RGRQRDGERQ RERDGGRQRD GEKDRERERD
GGRQRDGERQ RERDGGRQRD GERDRERERD GGRQRDGDRD REQERDGGRQ RDVERDQERE
RDGGRQRDGE RDRERERDGG RQRDGVRDRK RERDGGRQRD EERVRERERD RDRERDRGNG
KHRDHSRERE HRRN
//
