ID Q4RU50_TETNG Unreviewed; 1044 AA.
AC Q4RU50;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=(spotted green pufferfish) hypothetical protein {ECO:0000313|EMBL:CAG08082.1};
GN ORFNames=GSTENG00028953001 {ECO:0000313|EMBL:CAG08082.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG08082.1};
RN [1] {ECO:0000313|EMBL:CAG08082.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG08082.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU000687}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAG08082.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CAAE01014995; CAG08082.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4RU50; -.
DR KEGG; tng:GSTEN00028953G001; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd19063; LGIC_TM_5-HT3; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 3.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF764; 5-HYDROXYTRYPTAMINE RECEPTOR 3E; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 3.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 2.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 3.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT TRANSMEM 163..186
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 198..215
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 227..250
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 10..162
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 169..284
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT DOMAIN 401..519
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 740..855
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT REGION 921..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 118001 MW; A77AD0597973F228 CRC64;
MFNCVCPVKE WDIEGLSWDA EECGTQRVSL PREKLWIPDI HITEFMDEDK SPRTPYVYIY
NTGHVFDDSP LRVVSTCKLG IYSFPFDIQN CSLTFGSYIH FDTDIQMFAS TTAAEILEES
LSVAQTKGEW ELINIQVFPS VLEITDGKYS QLKYYLILRR RPILYVINLI LPSIFLVTLD
VFSFLLPPHS VDRSSFKMTL ILGYTVFLLL MNDLLPVTGN ETPLLNVFFS LSFALMVASL
LATLFITNIY FCSAHFGAVP HWLRTLMLKY AAVIVCLPPK KRSNRITVSL HENGKDLAPT
VISSSDLQGL SEAPSVEPPN NSILTEVKKL AKDLFVDLLS YRNEELCQKV PSASPAGGLW
CFIGLVFRPL CGSVCWCELS CEEGHSGPTY ESLQAVFDLQ AFRPAVNLSR PTTTNISFTL
YAVLGVNEKT QILSTFLWLR LFWHHDFLVW DPDECDGVTK ISLPVKNLWS PDIIVYELSV
SLNNHPLTRM VCFTCFPFLM VTMKGSFTYS VDDDVSQACP YVYVNHTGHI RWDRMLRLVS
ACNLRDLQLS LRLKDVRVGP ALTFEEMSKN SKRYLEASGE WELMDILGET SILQFGIDEW
DIITFWVVIR RRPVLYVAHV RYQNFNRSVG TWTSSTATWP PCRRRASCGT SGATSATSWT
FSSSASTCCS SPATLWWSSS CGASGSDAVS QALTMLIWQV LGLTIPTVPW LLQEWDIEEL
SWDERECGAR EDKSPVIPYM YLFNTGGVYD DRPIRVVSSC KLEIYTFPFD IQNCTLTFGS
YMHYGLTFGL FGTKASDIRM TPGNTAEEAL QESRQVFVTN GEWSLADIQI SPFTLSLDED
SYSEVKYFLI LRRKPINYVV NLLIPSCFLI MVDIFSFLLP PHSVDRSSFK MTLILRLHRL
PAHHERPAAR HRGPDAAHQR LLLHQPGPDG GQPAGDGDNH KYPAKLHPRP HPRLAQDPGV
TLPGLRRLSP STQEEEGGGQ ALPGEPLDEG VGDDREGAGP FPLRPLHHPH HGHLRHHHRH
LDLEQLIRTL SWTLEINPGF KLLL
//
