ID Q4RWH8_TETNG Unreviewed; 601 AA.
AC Q4RWH8;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=All-trans-retinol 13,14-reductase {ECO:0000256|ARBA:ARBA00041141};
DE EC=1.3.99.23 {ECO:0000256|ARBA:ARBA00038979};
DE Flags: Fragment;
GN ORFNames=GSTENG00027856001 {ECO:0000313|EMBL:CAG07254.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG07254.1};
RN [1] {ECO:0000313|EMBL:CAG07254.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG07254.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol;
CC Xref=Rhea:RHEA:19193, ChEBI:CHEBI:13193, ChEBI:CHEBI:17336,
CC ChEBI:CHEBI:17499, ChEBI:CHEBI:52075; EC=1.3.99.23;
CC Evidence={ECO:0000256|ARBA:ARBA00036004};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}.
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DR EMBL; CAAE01014987; CAG07254.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4RWH8; -.
DR KEGG; tng:GSTEN00027856G001; -.
DR HOGENOM; CLU_019722_1_0_1; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR46091:SF1; ALL-TRANS-RETINOL 13,14-REDUCTASE; 1.
DR PANTHER; PTHR46091; BLR7054 PROTEIN; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT NON_TER 601
FT /evidence="ECO:0000313|EMBL:CAG07254.1"
SQ SEQUENCE 601 AA; 66695 MW; F30A14ED224BD132 CRC64;
MLLSVGIISV ALVVFIIKYV FGSSGPNPFE KDTRVPLKPI VHHRKEKNKV LKQGFLVSKV
PENLDAIIIG SGIGGLGLAV LLAKVGKKVL VLEQHDRAGG CCHTFCEKGF EFDVGIHYIG
DLLDHKPFRC MLDQMTDGQL QWEPLENPFD QVVIGPPDNR RRYPIYSGSR RFPEELKKCF
PGEEAAIDQY LKLVKKAGRG VWLLALLKIC PAPLAKFLAA TGLAKRLSFF FKMASRSLTE
VVNQLTDNKD LRAVFSYIFG TYGNMPKDAS FSMHSLLVAH YLNGAWYPRG GATEIAYHMI
PIIEKAGGAV LVRAPVNRIL FNEAREACGV SVLKGQEEVH IRAPMVISDA GIFNTYQTLL
PKELRALPDI QKQLSLMKNG EGGLSIFLGL AGTKEELGLK ADNYWIFSEN NLDELVEKYL
SGEREDSARK VPLLFVASPS AKDPTWEERS PGKSTLSLVT FANYKWFEEW KEDKVTNRGA
EYKELKQAFM DSILEVVLDV FPKITREKIE YMDAGTPITN THYIGAPRGE IYGADHGTAR
FSPELNATVR PQTPLRNLYL TGQDAFLCGF AGALAGALSC GSVILNRNLH LDAISLAKRT
K
//
