ID Q4RXS8_TETNG Unreviewed; 905 AA.
AC Q4RXS8;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Metabotropic glutamate receptor 3 {ECO:0000256|ARBA:ARBA00020281};
GN ORFNames=GSTENG00027300001 {ECO:0000313|EMBL:CAG06804.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG06804.1};
RN [1] {ECO:0000313|EMBL:CAG06804.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG06804.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: G-protein coupled receptor for glutamate. Ligand binding
CC causes a conformation change that triggers signaling via guanine
CC nucleotide-binding proteins (G proteins) and modulates the activity of
CC down-stream effectors. Signaling inhibits adenylate cyclase activity.
CC {ECO:0000256|ARBA:ARBA00025645}.
CC -!- SUBUNIT: Interacts with TAMALIN. {ECO:0000256|ARBA:ARBA00011150}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAG06804.1}.
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DR EMBL; CAAE01014979; CAG06804.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4RXS8; -.
DR KEGG; tng:GSTEN00027300G001; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001234; GPCR_3_mGluR3.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF147; METABOTROPIC GLUTAMATE RECEPTOR 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 2.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01053; MTABOTROPC3R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 2.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 576..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 738..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 769..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 577..863
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAG06804.1"
SQ SEQUENCE 905 AA; 101591 MW; 7DB25B1D25963594 CRC64;
SKREITLEGD LMIGGLFPVH QKGEAAQDCG KINAQRGIQR LEAMLLALDE INRDERILPG
IKLGAHILDT CSKDTYALEQ SLEFVRASLT KVDDSEYTCP DGSYAIHDDI PLAISGVIGG
SYSDVSIQTG KLRKNRHYCK HRYGNMAEHV EPTGGWQNSS EIEPVANLLR LFQIPQISYA
STSAKLSDKT RYDYFARTVP PDFYQAKAIA EILRYFNWTY VSTVASEGDY GETGIDAFQQ
EARARQICIA TSAKVSRSMS RWSYENVIRS LQQKSNAKVV ILFTRSEDAR ELLVAANRMN
VTFTWVASDG WGAQESVVRG SEAVADGAFT IELASYQIPR FNDYFTALHP YNNSRNPWFR
EFWENQFQCS LHELSCGKHS LREAPFQPES KIMFVVNAVY AMAAALHNMR QALCPNSTRV
CDALKRGNGR KFYRDYILKV KFDAPFRPPD TENVVRFDGF GDSLGRYNIF HYHKDGERYV
YQKVGYWAQG LSLNTSLIPW AGHGAPTSQC SDPCRKNEVK SMQPGDVCCW ICIPCQPYQY
LQDEFTCADC SFGQWPLANL TGCYDLPEEY IRWEDAWAIG PVTVSCLGMM CTLFIVGLFL
KHNETPVVKA SGRELSYILL LGVLMCYSMT FIYIAKPSTA VCTLRRLGLG TSFAVCYSAL
LTKTNRIARI FSGVKDGAQR PRFISPASQV AICGALISCQ LVVVIVWLLV EAPGVRKEVS
PERRDVVTLK CNSKDSSMLM SLTYNCILII LCTVYAFKTR KCPENFNEAK FIGFTMYTTC
IIWLAFQPIF YVTASDYRVS PYCSEKHCLQ AKGCQGTLVQ TTTMCISVSL SGSVVLGCLF
APKVHIILFQ PQKNVCTLRV ATTRFSPPTL SRPCATDGRS WTPQPRPCES RLGSSARRCK
QIFNL
//
