ID Q4TTF0_CAERE Unreviewed; 404 AA.
AC Q4TTF0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN Name=RAF {ECO:0000313|EMBL:AAY54270.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|EMBL:AAY54270.1};
RN [1] {ECO:0000313|EMBL:AAY54270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EM464 {ECO:0000313|EMBL:AAY54270.1};
RA Ramachandran U., Nemeroff M.E.;
RT "Isolation of a mRNA for the RAF proto-oncogene serine/threonine kinase of
RT Caenorhabditis remanei.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DQ072253; AAY54270.1; -; mRNA.
DR AlphaFoldDB; Q4TTF0; -.
DR HOGENOM; CLU_023684_1_0_1; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20811; C1_Raf; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF02196; RBD; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00455; RBD; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50898; RBD; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 2: Evidence at transcript level;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 45..121
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 130..177
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAY54270.1"
FT NON_TER 404
FT /evidence="ECO:0000313|EMBL:AAY54270.1"
SQ SEQUENCE 404 AA; 43863 MW; 458CEABA2E617644 CRC64;
DQASPMASPS TPLYPKHSDS LHSLSGHDHS GVGTSDKEPP KFKYKMIMVH LPFDQHSRVE
VRPGETARDA ISKLLKKRNI TPQLCHVNTS PDPKQESIDL SLTMEEIASR LPGNELWVHS
EYLNTVSSIK HAIVRRTFIP PKSCDVCNNP IWMMGFRCEF CQFKFHQRCS SFAPLYCDLL
QSVPKNEDLV KQLFGIASEV EGPDRSVAEI VLAGLAPTSG QSPAATPDSS HPDLTSIKRT
GGVKRHPLTV SPQAETAQLS PAGPYPRDRS SSAPNINAIN DEATVQHNQR ILDALEAKRL
EEESKDKTGS LLSTQARRPH CYSGGHILPG ARMNRLHPLV DCTPLGSNSP SSTCSSPPGG
LIGQPSNVTG STTSSLVAAH LHALPLTPPQ SAPPQKISPG FFRN
//
