ID Q4UC33_THEAN Unreviewed; 716 AA.
AC Q4UC33;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Neutral sphingomyelinase, putative {ECO:0000313|EMBL:CAI75618.1};
GN ORFNames=TA04385 {ECO:0000313|EMBL:CAI75618.1};
OS Theileria annulata.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=5874 {ECO:0000313|EMBL:CAI75618.1, ECO:0000313|Proteomes:UP000001950};
RN [1] {ECO:0000313|EMBL:CAI75618.1, ECO:0000313|Proteomes:UP000001950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ankara {ECO:0000313|Proteomes:UP000001950};
RX PubMed=15994557; DOI=10.1126/science.1110418;
RA Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W.,
RA Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R.,
RA Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A.,
RA Griffiths-Jones S., Harris D.E., Katzer F., Larke N., Lord A., Maser P.,
RA McKellar S., Mooney P., Morton F., Nene V., O'Neil S., Price C.,
RA Quail M.A., Rabbinowitsch E., Rawlings N.D., Rutter S., Saunders D.,
RA Seeger K., Shah T., Squares R., Squares S., Tivey A., Walker A.R.,
RA Woodward J., Dobbelaere D.A.E., Langsley G., Rajandream M.A., McKeever D.,
RA Shiels B., Tait A., Barrell B.G., Hall N.;
RT "Genome of the host-cell transforming parasite Theileria annulata compared
RT with T. parva.";
RL Science 309:131-133(2005).
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DR EMBL; CR940352; CAI75618.1; -; Genomic_DNA.
DR RefSeq; XP_955094.1; XM_950001.1.
DR AlphaFoldDB; Q4UC33; -.
DR STRING; 5874.Q4UC33; -.
DR GeneID; 3865232; -.
DR KEGG; tan:TA04385; -.
DR VEuPathDB; PiroplasmaDB:TA04385; -.
DR eggNOG; KOG1786; Eukaryota.
DR InParanoid; Q4UC33; -.
DR OMA; QVREFGQ; -.
DR OrthoDB; 47483at2759; -.
DR Proteomes; UP000001950; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR PANTHER; PTHR13743:SF112; BEACH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR Pfam; PF02138; Beach; 1.
DR SMART; SM01026; Beach; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001950};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 695..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 239..350
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 358..690
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 461..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 81630 MW; 83E20387A3E34BA6 CRC64;
MLSTVRSFDL VLLEEGEEYV TDAACTLFTS FPNQSTFNTN STHNNNVISS NTSSSNRNNV
ENVYNKGRIR IGTKSLIFEP DSLDMPLLKL QFQHITHIQH HNNSCNSNNV NSMNNGVNVD
ENGILVCSKQ VTSIPTSIYN GKSRFITPYT TYTINNSTNN ITNLGNIRDA GLGRLELENI
SCYTFLFIYS TADIQKQQFI IFNSLLNSIQ NSIPVPNTIP YGTGVVGVSM GIIPNREKLI
LGVGKESVYC WRLKRMVRHG GFCALTDRAL YFQPSPNFSR KLFKRINLDS VLHIFKRDSG
LTSTGECLTA LEVVSLPEEI TDKIKRKQYR CIYLEFKQGS DRDKLVNALK DIVPKAFFAI
DSRGFRNEMT ELWRMGLLPN FQYLDFLNCI AGRSRYDISH YPVFPWVLTD YSSPTLDLNN
QNVYRDLSKP IGSLNIERLH LIKKRMYNLF LSNSVNNMDK GSEGNLKNRD TSGKNMNGSK
SVKSGDEDLW DMGYYIYGSH YSTPALIVFF LIRLLPECQL RLYGGRFDSS SRTFNNIQHT
YENVMNGHSS FFELIPEFYE SDELFLKNSL NITTQDGRLG DVELPKWAHN SPTQFLKIMR
SALESDYVSK NLTNWIDLIF GYKQSGQNSI VNNNTYHPLT YLGSVHAGKL RTTSAIQNLL
KTMDSHAISV QVREFGQSPI LLFDTPHPRK YVFRALKTCF SLLGLIFTIY TSYIYI
//
