ID Q4VHC1_NAEGR Unreviewed; 442 AA.
AC Q4VHC1;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Tubulin gamma chain {ECO:0000256|RuleBase:RU000352};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|EMBL:AAY17321.1};
RN [1] {ECO:0000313|EMBL:AAY17321.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15939759; DOI=10.1083/jcb.200410052;
RA Kim H.K., Kang J.G., Yumura S., Walsh C.J., Cho J.W., Lee J.;
RT "De novo formation of basal bodies in Naegleria gruberi: regulation by
RT phosphorylation.";
RL J. Cell Biol. 169:719-724(2005).
RN [2] {ECO:0000313|EMBL:AAY17321.1}
RP NUCLEOTIDE SEQUENCE.
RA Lee Y.K., Lee J.H.;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Tubulin is the major constituent of microtubules, a cylinder
CC consisting of laterally associated linear protofilaments composed of
CC alpha- and beta-tubulin heterodimers. Microtubules grow by the addition
CC of GTP-tubulin dimers to the microtubule end, where a stabilizing cap
CC forms. Below the cap, tubulin dimers are in GDP-bound state, owing to
CC GTPase activity of alpha-tubulin. {ECO:0000256|ARBA:ARBA00034296}.
CC -!- FUNCTION: Tubulin is the major constituent of microtubules. The gamma
CC chain is found at microtubule organizing centers (MTOC) such as the
CC spindle poles or the centrosome. {ECO:0000256|RuleBase:RU000352}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR EMBL; AY919610; AAY17321.1; -; mRNA.
DR AlphaFoldDB; Q4VHC1; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_56069; -.
DR GO; GO:0000930; C:gamma-tubulin complex; IEA:InterPro.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR CDD; cd02188; gamma_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002454; Gamma_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF7; TUBULIN GAMMA CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01164; GAMMATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 2: Evidence at transcript level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352}.
FT DOMAIN 49..247
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 249..390
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
SQ SEQUENCE 442 AA; 49423 MW; 9E1E6DFC8D6717A3 CRC64;
MPREIITLQA GQCGNQIGTE FWKRLCLEHG IGTDGVLEDF AIQGAGDRKD VFFYQADDEH
YIPRSVIVDL ETRVIEGIKK SHRNLFNPEN IYMPGDGGGA GNNWANGFQL AEKYHEKLMD
IIDREADNSD SMEGFVLLHS IAGGTGSGLG SYLLEKLNDR YPKKLIQTYS VFPSYEAASD
VVVQSYNSML ALKRLILNAD SVVVLDNTAL NQIATERLKI PNPSVDNINS LVSTIMAATT
TTLRYPGYMN NDLVGLIASL VPTPRCHFLM TSYTPLSVVD NQAKIQKTSV LDVMRRLLNP
KNIMVSSNIK KGCYVSILNI IQGEVDPTQV HKSLSLIRKK NLANFIPWGP SSIQVVLSKR
SPYVQTQNRV SGLMMANHTS LGSLCQTILK NFLKQYKSKA FTQNYMESFE SKDEFEDSKE
VVSSLIEEYK QSESENYLSM QQ
//
