ID Q4VK41_DROSU Unreviewed; 243 AA.
AC Q4VK41;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=Alcohol dehydrogenase {ECO:0000256|ARBA:ARBA00016352, ECO:0000256|RuleBase:RU000364};
DE EC=1.1.1.1 {ECO:0000256|ARBA:ARBA00013190, ECO:0000256|RuleBase:RU000364};
DE Flags: Fragment;
GN Name=AdhT {ECO:0000313|FlyBase:FBgn0083401};
GN Synonyms=Adh-Twain {ECO:0000313|EMBL:AAY53959.1};
OS Drosophila subobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7241 {ECO:0000313|EMBL:AAY53959.1};
RN [1] {ECO:0000313|EMBL:AAY53959.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Line 1 {ECO:0000313|EMBL:AAY53956.1}, Line 24
RC {ECO:0000313|EMBL:AAY53965.1}, Line 26 {ECO:0000313|EMBL:AAY53966.1},
RC and Line 7 {ECO:0000313|EMBL:AAY53959.1};
RX PubMed=15781692; DOI=10.1534/genetics.104.037283;
RA Jones C.D., Custer A.W., Begun D.J.;
RT "Origin and evolution of a chimeric fusion gene in Drosophila subobscura,
RT D. madeirensis and D. guanche.";
RL Genetics 170:207-219(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH;
CC Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC Evidence={ECO:0000256|RuleBase:RU000364};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH;
CC Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087,
CC ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000781,
CC ECO:0000256|RuleBase:RU000364};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738,
CC ECO:0000256|RuleBase:RU000364}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484, ECO:0000256|RuleBase:RU000363}.
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DR EMBL; AY874362; AAY53956.1; -; Genomic_DNA.
DR EMBL; AY874365; AAY53959.1; -; Genomic_DNA.
DR EMBL; AY874371; AAY53965.1; -; Genomic_DNA.
DR EMBL; AY874372; AAY53966.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4VK41; -.
DR FlyBase; FBgn0083401; Dsub\AdhT.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR CDD; cd05323; ADH_SDR_c_like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002425; ADH_Drosophila-type.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR44229; 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]; 1.
DR PANTHER; PTHR44229:SF8; ALCOHOL DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR01168; ALCDHDRGNASE.
DR PRINTS; PR01167; INSADHFAMILY.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|RuleBase:RU000364};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT NON_TER 243
FT /evidence="ECO:0000313|EMBL:AAY53959.1"
SQ SEQUENCE 243 AA; 26369 MW; 3A251A9D345A3318 CRC64;
MSLTNKNVVF VAGLGCIGLD TSKELVKRDL KNLVILDRID NPDAIAELKA INPKVTVTFF
PYDVTAPLAE TAKLLKCIFS QFKTVDILIN GAGILDDHQI ERTIAVNYTG LVNTTTAILD
FWDKRKCGPG GIICNIGSVT GFNAIYQVPV YSGSKAAVVN FTSSLAKLAP ITGVTAYTVN
PGITKTTLVQ KFNSWLDVEP KVAEKLLEHP TQTTQQCAKN FVKAIELNKN GALWKLDLGT
LEP
//
