ID Q4WTX6_ASPFU Unreviewed; 961 AA.
AC Q4WTX6;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Vacuolar protein sorting protein DigA {ECO:0000313|EMBL:EAL91950.1};
GN ORFNames=AFUA_5G06450 {ECO:0000313|EMBL:EAL91950.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL91950.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL91950.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the VPS18 family.
CC {ECO:0000256|ARBA:ARBA00010454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL91950.1}.
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DR EMBL; AAHF01000003; EAL91950.1; -; Genomic_DNA.
DR RefSeq; XP_753988.1; XM_748895.1.
DR AlphaFoldDB; Q4WTX6; -.
DR STRING; 330879.Q4WTX6; -.
DR EnsemblFungi; EAL91950; EAL91950; AFUA_5G06450.
DR GeneID; 3511155; -.
DR KEGG; afm:AFUA_5G06450; -.
DR eggNOG; KOG2034; Eukaryota.
DR HOGENOM; CLU_003488_0_0_1; -.
DR InParanoid; Q4WTX6; -.
DR OMA; WIQREKW; -.
DR OrthoDB; 22879at2759; -.
DR Proteomes; UP000002530; Chromosome 5.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0048284; P:organelle fusion; IBA:GO_Central.
DR GO; GO:0007033; P:vacuole organization; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR CDD; cd16462; RING-H2_Pep3p-like; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR007810; Pep3_Vps18.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR Pfam; PF05131; Pep3_Vps18; 1.
DR PROSITE; PS50236; CHCR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 25..431
FT /note="Pep3/Vps18/deep orange beta-propeller"
FT /evidence="ECO:0000259|Pfam:PF05131"
FT COILED 811..845
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 961 AA; 107885 MW; 3DFF555CF64770E7 CRC64;
MVLNASSGYV APSNLAEAPD ASLSMFDVRR VQLQFPLAAD FVAAQVANNV LILALSTNRI
LRIDLDTPED IDDIDLPKKS SEVGVIRRMF LDPTASHLII TTTLGENYYL HTQSRHPKSL
SRLKGVSIES VAWSPSLPTA STREILLGAT DGQIWETYIE PSTEFYRREE KYAHSVYKAL
EGSPVTGIWT ELVPTTPEQR RVLIATHGKL ICFQGRAGRQ GSQGIYAELF QREAPVLYEI
QKPSGAAPST LVISATAVDG HNVDSYAEKE FAWLSSQGIY HGQLPFASGK EKGPFEGARM
LPRSMFPPTE SARGGKKLIQ DPITAMTLSQ WHILALVEGK IVAVNRMSDE IIYEQAVLEP
GQSTLGLLTD SMQHTYWLFT SQEIFEIVAE DEDRDVWKVF LQKQMFDQAL EYARGSAQKD
AVATASGDFL ASKGRYLEAA KVWGKSSKGF EEVCLTLINR NEHDALRKYL LTQLSTYKKS
STMQRIMVAS WLVEVFMSKL NALDDNIATK AELAEGASTE DIKDELSNVR AEFQEFVNKY
KTDLDKKTAY DIISSHGREE ELLFFATATN DYNYVLSYWI QREKWSEALN VLQKQTDPDV
FYKYSSVLMT HAATGLVDIL MRQTNLEPER LIPALLNYNK TVNVPLSQNQ AVRYLNFIVV
NHPKPSAAVH NTLISIHASS PSPSEAGLLT YLQSQPSSPP PYDADFALRL CIQHERVQSC
IHIYSAMGQY LQAVELALQH EDIELAAIVA DRPEGNDKLR KKLWLLVAEK KIRQPGTGIK
DAIEFLRRCE LLRIEDLIPF FPDFVVIDDF KDEICSALED YSRHIDALRQ EMDNSAQTAR
QIRSEIAALD MRYAIVEPGE KCWTCSLPLL SRQFFVFPCQ HAFHSDCLGK EVLEGAGGKK
KYIRDLQAQL NKADVSASRR EEIVKELDGL VAEACILCGD HAIKQIDKPF ITDADIDEWA
L
//