ID Q4WWL3_ASPFU Unreviewed; 669 AA.
AC Q4WWL3;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Rho GTPase activator (Rgd1), putative {ECO:0000313|EMBL:EAL92940.1};
GN ORFNames=AFUA_3G06280 {ECO:0000313|EMBL:EAL92940.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL92940.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL92940.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL92940.1}.
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DR EMBL; AAHF01000002; EAL92940.1; -; Genomic_DNA.
DR RefSeq; XP_754978.1; XM_749885.1.
DR AlphaFoldDB; Q4WWL3; -.
DR STRING; 330879.Q4WWL3; -.
DR EnsemblFungi; EAL92940; EAL92940; AFUA_3G06280.
DR GeneID; 3511709; -.
DR KEGG; afm:AFUA_3G06280; -.
DR VEuPathDB; FungiDB:Afu3g06280; -.
DR eggNOG; KOG1450; Eukaryota.
DR HOGENOM; CLU_010730_3_0_1; -.
DR InParanoid; Q4WWL3; -.
DR OMA; DSGWQAR; -.
DR OrthoDB; 5482027at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07652; F-BAR_Rgd1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF138; RHO GTPASE ACTIVATOR; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 40..321
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 476..666
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 141..200
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 104..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..465
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 73144 MW; D164957159619F43 CRC64;
MAEVAAPDGS APIVPVLRDP DAPPSSAGSA GQSEVRPGPP PMTEELKARL DKVIYSDIGI
TTLLARLKQS VASAKDFSAF LKKRSSLEEE HAQGLRKLSR SLNDAASRPD NRQGTYGSSY
NDLNRFHERM ADHGLQFAVS LQQMADDLHE LATNIEKGRK QWKQTGLSAE KRVTEAEAAA
EKAKAKYESL AEQYDRVKTG DKQGGKFGLK GHKSAAQHEE ELLRKVQNAD GDYAAKVTAA
QTARRELIST HRPQAVQNIQ KLIAECDSGL TLQLQKFATF NEKLLLGQGL SITPLDEGAG
NGSIGPKSLY EVVRQIDNQK DFQDYILSYE HNPGAVTSEE VQYQRHPTLG GTPTPVAPAS
QPSTQNKRQS IMFPSSFSQQ HLPVSQPSTQ PSGPAATPSP APAPAQSTQP SSFQPHPDSF
SSPPPFQPPY PTSSGLPAPD QHNVNTLPMA APANPLPPPG NNFQQNLPPL RPVFGVSLED
LYARDGTAVP MIVYQCLQAI ELFGLDVEGI YRLSGSANHI NHMKSLFDND SSQVDFTNPE
NFYHDVNSVA GLLKQFFREL PDPLFTSRYY SDFINAARID DDIQRRDSLH ALVNNLPDAH
YATLRALILH LNKVQEHYMN NRMNAGNIAI CFGPTLMGAS SGGNIADAGW QVRVIETILV
NTFQIFDDD
//
