ID Q4WYW5_ASPFU Unreviewed; 828 AA.
AC Q4WYW5;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Isochorismatase family protein family {ECO:0000313|EMBL:EAL92138.1};
GN ORFNames=AFUA_3G14500 {ECO:0000313|EMBL:EAL92138.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL92138.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL92138.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL92138.1}.
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DR EMBL; AAHF01000002; EAL92138.1; -; Genomic_DNA.
DR RefSeq; XP_754176.1; XM_749083.1.
DR AlphaFoldDB; Q4WYW5; -.
DR STRING; 330879.Q4WYW5; -.
DR EnsemblFungi; EAL92138; EAL92138; AFUA_3G14500.
DR GeneID; 3512184; -.
DR KEGG; afm:AFUA_3G14500; -.
DR VEuPathDB; FungiDB:Afu3g14500; -.
DR eggNOG; ENOG502QRZN; Eukaryota.
DR HOGENOM; CLU_005335_0_0_1; -.
DR InParanoid; Q4WYW5; -.
DR OMA; KMYHLSG; -.
DR OrthoDB; 1644896at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051213; F:dioxygenase activity; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IEA:InterPro.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0035552; P:oxidative single-stranded DNA demethylation; IEA:InterPro.
DR CDD; cd00431; cysteine_hydrolases; 1.
DR CDD; cd00299; GST_C_family; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR032854; ALKBH3.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR31212; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3; 1.
DR PANTHER; PTHR31212:SF5; ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500); 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR Pfam; PF13410; GST_C_2; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
DR PROSITE; PS50405; GST_CTER; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 466..580
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT DOMAIN 700..828
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT REGION 313..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..380
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 828 AA; 92270 MW; 87BF2C02D6AB116A CRC64;
MSLLSAFSAL PTVQTRKALL LLDFQNDFVR PSGALHVPNA AEILENIAQL VTAFRRTGDV
IWVRSHYESH RPLIDSDFQD RIVLGRETDE QRKRAERPSS KTPVDEEAFL SSESSQCCRP
QSSGFQFPAP VLAAIDAEND TLMDKSDYSA LQDEGMILSL RTRFITELYL CGSLSNVSVY
ATALDAVRHG FSVTLIEDCL GFRDFVRHEE AMRRMADIFG ASGITTQELF EELDWQETDA
IARQSTHRPV RAVTPAGIEG VMDELDVKTI RGPTANEGTP ESLGSRRRRL DALLAEQTDG
EDDDPLDLTS LARSRSRYGP SGSPGSSSQA HGAGEKKARV RVRRTRRQDH KVDASNRTEE
RRSGKTKKSR DIRGPGDKIG EGDSRIIYDL DLPEDAFASI RSEVAWQKMY HMSGQVPRLV
AVQGQTRDDG SIPIYRHPAD ESPPLRPFTP TVNQIRIIVE RILGHPLNHV LIQLYRDGQD
SISEHSDKTL DIVRGSFICN VSLGAQRVMT LRNKVKAADE DQRPTQRISM PHESLFILGE
KTNMRWLHGI RPDKRQAAEK STEELAYGGE RISLTFRHIG TFLNEAGDAI WGQGAVSKDQ
SQANTVIHGD PAETERLVRA FGQENQATEF DWDAVYGGGF DVVNFVTTST AKLVEDSDPV
TNLRVRLALS ENGIRYEVSA SSEDENSTEG KARPVLITAD GTEVAGELDI MNFLAKHAPE
LTRAGVEVLR GGSQLLKINE LLQDWRTSHS NGEKINPESL DLWEKALDGQ YYLGGAALGL
DDCFLWPVLR DIVQTCGPFS IDEYPNLAQY YRRVEKRGIV KATLEELK
//
