ID Q4WZ82_ASPFU Unreviewed; 334 AA.
AC Q4WZ82;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=3-beta hydroxysteroid dehydrogenase/isomerase, putative {ECO:0000313|EMBL:EAL94083.1};
DE EC=1.1.1.195 {ECO:0000313|EMBL:EAL94083.1};
GN ORFNames=AFUA_2G17850 {ECO:0000313|EMBL:EAL94083.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL94083.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL94083.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL94083.1}.
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DR EMBL; AAHF01000001; EAL94083.1; -; Genomic_DNA.
DR RefSeq; XP_756121.1; XM_751028.1.
DR AlphaFoldDB; Q4WZ82; -.
DR STRING; 330879.Q4WZ82; -.
DR EnsemblFungi; EAL94083; EAL94083; AFUA_2G17850.
DR GeneID; 3513280; -.
DR KEGG; afm:AFUA_2G17850; -.
DR eggNOG; KOG1502; Eukaryota.
DR HOGENOM; CLU_007383_9_2_1; -.
DR InParanoid; Q4WZ82; -.
DR OMA; ICCAYNT; -.
DR OrthoDB; 1848657at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0045551; F:cinnamyl-alcohol dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0052747; F:sinapyl alcohol dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR PANTHER; PTHR10366:SF812; PUTATIVE-RELATED; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EAL94083.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 8..252
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 334 AA; 36309 MW; AEA0290C2D768363 CRC64;
MPAGLIFITG ATGFIGSAVA LEALNAGYSL RISIRKESQI PKLKKILSQF EDKIEFVVVP
DITQESSFAG KLEGVEYVLH LASPLPHGTN KETYFGPAVK GTTAILKEAA KVSTVKRVVI
TSSMAALIPL TGVPEGEFVR EDTGWDLSVD PNADFTGPDD AATSFRLYRA SKLLANNASW
EFRNTAKPHF ALVTLHPAYV FGHNHVQTSP EEVQGGTNGM LWGTIMTGKP MGNSTGVHVR
DVAEAHIKAL DETVPDGSKF LLAGKRASWS DVARIVKRDY PDIGAKITED ISGEPFPLDT
TEAEKVLGMK WRSLDQMVKD VVDQQLELMR QTSL
//
