ID Q4X240_ASPFU Unreviewed; 685 AA.
AC Q4X240;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Acyl-CoA synthetase, putative {ECO:0000313|EMBL:EAL93075.1};
DE EC=6.2.1.- {ECO:0000313|EMBL:EAL93075.1};
GN ORFNames=AFUA_2G07780 {ECO:0000313|EMBL:EAL93075.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL93075.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL93075.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL93075.1}.
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DR EMBL; AAHF01000001; EAL93075.1; -; Genomic_DNA.
DR RefSeq; XP_755113.1; XM_750020.1.
DR AlphaFoldDB; Q4X240; -.
DR STRING; 330879.Q4X240; -.
DR EnsemblFungi; EAL93075; EAL93075; AFUA_2G07780.
DR GeneID; 3513138; -.
DR KEGG; afm:AFUA_2G07780; -.
DR VEuPathDB; FungiDB:Afu2g07780; -.
DR eggNOG; KOG1175; Eukaryota.
DR HOGENOM; CLU_000022_3_5_1; -.
DR InParanoid; Q4X240; -.
DR OMA; FIMGRTD; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IBA:GO_Central.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:EAL93075.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 5..66
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 70..486
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 552..634
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 685 AA; 74834 MW; ACC5BDF57C617F8E CRC64;
MSTQQTVHAQ SLHSPESFWS YHATKLHWHK KPSQTLVRRP KTLPSGVTHE HWSWFPDGEI
STTYNCVDRH VAAGRGENVA IIWDSPVTGV KEKYTYSQLL DEVEVLAGVL REEGVRKGDV
VIIYMPMIPA ALIAALAITR LGAIHSAVFG GFAAKSLAQR IEAAKPRVIM TASCGIEGSK
GPVSYRPLVE GAIAASSFKP SKTIIWQRDQ LRWNNPDKMG GQRNWQRLVK SARMRGVKAG
PVPVKSTDGL YIIYTSGTTG LPKGVFREAG GHAVGLHLSI KYLFDIHGPG DVMFCASDIG
WVVGHSYILY APLLVGATTV LFEGKPVGTP DAGTFWRIVE EHKVKVLSTA PTAIRAIRKD
DPDNKYFLQV ARRGGLRHLK ALFLAGERSE PSIVQMFQEL LTQHAAPGAM VIDNWWSSES
GSPISGLALN SAAGLVDQWQ PNQDSKPLAV RPGSAGLPMP GFDVRVVDDE GREVPRGTMG
NIVMAMPLAP TAFTSLFKDD ERFYRGYVKR FNGRWVDTGD AGMIDEDGYI HIMSRSDDII
NVAAHRFSTG AIEQAILSHP DIGEASVVGM PDPLKGHLPF AFIQPRGSGP LPARPSAELF
HAVNQLVREQ IGAIASLGGI IQGRGMIPKT RSGKTLRRVL RELVENGVRG EFDAPVNVPP
TVEDAEVVEV ARERVREYFA AKARL
//
