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Database: UniProt
Entry: Q4Z4T1_PLABA
LinkDB: Q4Z4T1_PLABA
Original site: Q4Z4T1_PLABA 
ID   Q4Z4T1_PLABA            Unreviewed;       953 AA.
AC   Q4Z4T1;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   05-JUL-2017, entry version 54.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=PB000782.00.0 {ECO:0000313|EMBL:CAH94701.1};
OS   Plasmodium berghei (strain Anka).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX   NCBI_TaxID=5823 {ECO:0000313|Proteomes:UP000007720};
RN   [1] {ECO:0000313|EMBL:CAH94701.1, ECO:0000313|Proteomes:UP000007720}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ANKA {ECO:0000313|Proteomes:UP000007720};
RX   PubMed=15637271; DOI=10.1126/science.1103717;
RA   Hall N., Karras M., Raine J.D., Carlton J.M., Kooij T.W.A.,
RA   Berriman M., Florens L., Janssen C.S., Pain A., Christophides G.K.,
RA   James K., Rutherford K., Harris B., Harris D., Churcher C.M.,
RA   Quail M.A., Ormond D., Doggett J., Trueman H.E., Mendoza J.,
RA   Bidwell S.L., Rajandream M.A., Carucci D.J., Yates J.R. III,
RA   Kafatos F.C., Janse C.J., Barrell B.G., Turner C.M.R., Waters A.P.,
RA   Sinden R.S.;
RT   "A comprehensive survey of the Plasmodium life cycle by genomic,
RT   transcriptomic, and proteomic analyses.";
RL   Science 307:82-86(2005).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CAAI01000589; CAH94701.1; -; Genomic_DNA.
DR   RefSeq; XP_677707.1; XM_672615.1.
DR   STRING; 5821.PBANKA_122380; -.
DR   EnsemblProtists; CAH94701; CAH94701; PB000782.00.0.
DR   EnsemblProtists; CDS49376; CDS49376; PBANKA_122380.
DR   GeneID; 3426255; -.
DR   KEGG; pbe:PB000782.00.0; -.
DR   EuPathDB; PlasmoDB:PBANKA_1223800; -.
DR   HOGENOM; HOG000037059; -.
DR   KO; K02154; -.
DR   Proteomes; UP000007720; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007720};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007720};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    479       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    511    528       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    598    619       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    631    654       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    692    715       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    886    909       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      297    324       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   953 AA;  111080 MW;  4229717D155432B1 CRC64;
     MGIFRSETMK HGTLVLPADR AREYMDCLGK QVDIQFIDMN EKTMKRQYKK YIQRIDDMER
     ILRFLEENIN KLPNVKIKKS KIENFLEHDN IYELDQVEES LNRLHVQFVR FCNNNKDLVD
     ERNSAIEEKH VILTALNQLH PDMSKRSNLR TIHEDNIDEN NLMNNSEEDA SLSTHIMREG
     INMMFTNISG VIKTKDQESF SRTIFRALRG NTYTYFQNID ENMSNTDTLN NESSSMDNKI
     GENNNENKEN NSGGNNNELK SVFVVYCHGS THSSIYEKIM KICKAYDVRN YEWPKTYEQA
     NKRLNELKEI INDKEKALKA YEEYFINEIF VLINVVEPNK NSLIEEWKLF CKKERHIYNN
     LNYFEGSDIT LRCDCWYSVN DEEKIRHILM NKSTNDLVSA LLLSDKLLTP NISPPTYIKT
     NEFTNTYQSM VDTYGIPRYG EINPAISTIV TFPFLFGIMY GDVGHGICIF LFALFLIIVH
     NRMKNKDSNS SGGNGGENNN EMLNMLFNGR YMLLLMGFFA IYAGFLYNDF FSMPLNLFTS
     MFEVDKVVDS VEYYKRKQIL NAETGQMENA PPYIFGFDSK WLGADNELTY INSFKMKFSI
     IIGFFHMTFG VIIKGFNALY FKKKMDFFFE FLPQLVMMLS MIGYLVFLII YKWITPIGYG
     GYKKQGIINT IINMYLLKEI NKDNQFYEHQ EIVQIIIITL FALCIPIMLI CKPAIKTYKM
     IKEKKKRMAI HYQTVEKEMT NQFGGVGLIG AGIDEKNMIY SYGNNSMHKR VTKIGYDNIG
     AKNEDEYLLL KRKGKKTDDE MEAHLLGPSS YHSSNASNTN ESFDEHEENI SEIWIEQLIE
     TIEFILGLIS NTASYLRLWA LSLAHQQLSL VFFEQTILSS LEKNTFMGVL ISLIIFSQLF
     SILTIAVILC MDTLECFLHS LRLQWVEFQN KFYKGDGIPF KPFNIKKLLS DRE
//
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