ID Q50B46_9HIV1 Unreviewed; 234 AA.
AC Q50B46;
DT 07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2005, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Protease {ECO:0000313|EMBL:AAY31727.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAY31727.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAY31727.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAY31727.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=758 {ECO:0000313|EMBL:AAY31727.1};
RX PubMed=15839752; DOI=10.1371/journal.pmed.0020112;
RA Kantor R., Katzenstein D.A., Efron B., Carvalho A.P., Wynhoven B., Cane P.,
RA Clarke J., Sirivichayakul S., Soares M.A., Snoeck J., Pillay C., Rudich H.,
RA Rodrigues R., Holguin A., Ariyoshi K., Bouzas M.B., Cahn P., Sugiura W.,
RA Soriano V., Brigido L.F., Grossman Z., Morris L., Vandamme A.M., Tanuri A.,
RA Phanuphak P., Weber J.N., Pillay D., Harrigan P.R., Camacho R.,
RA Schapiro J.M., Shafer R.W.;
RT "Impact of HIV-1 Subtype and Antiretroviral Therapy on Protease and Reverse
RT Transcriptase Genotype: Results of a Global Collaboration.";
RL PLoS Med. 2:E112-E112(2005).
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DR EMBL; AY901376; AAY31727.1; -; Genomic_RNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000313|EMBL:AAY31727.1};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 44..234
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAY31727.1"
FT NON_TER 234
FT /evidence="ECO:0000313|EMBL:AAY31727.1"
SQ SEQUENCE 234 AA; 27095 MW; 4DF5011DC0D84548 CRC64;
PISPIETVPV KLKPGMDGPK VKQWPLTEEK IKALTEICEE MEKEGKISKI GPENPYNTPV
FAIKKKDSNK WRKLVDFREL NKRTQDFWEV QLGIPHPAGL KKNKSVTVLD VGDAYFSVPL
DESFRKYTAF TIPSINNETP GIRYQYNVLP QGWKGSPAIF QSSMTKILEP FRAQHPEVVI
YQYVDDLYVG SDLEIGQHRE TIEKLREHLL RWGFTTPDKK HQKEPPFLWL GYEL
//
