ID Q52S20_SIV Unreviewed; 886 AA.
AC Q52S20;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 2.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAX85828.2};
OS Simian immunodeficiency virus (SIV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11723 {ECO:0000313|EMBL:AAX85828.2};
OH NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AAX85828.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CK36 {ECO:0000313|EMBL:AAX85828.2};
RX PubMed=16571789; DOI=10.1128/JVI.80.8.3721-3731.2006;
RA Rychert J., Lacour N., Amedee A.M.;
RT "Genetic analysis of simian immunodeficiency virus expressed in milk and
RT selectively transmitted through breastfeeding.";
RL J. Virol. 80:3721-3731(2006).
RN [2] {ECO:0000313|EMBL:AAX85828.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CK36 {ECO:0000313|EMBL:AAX85828.2};
RA Amedee A.M., Rychert J.A., Lacour N.;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; AY971377; AAX85828.2; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AAX85828.2};
KW Virion {ECO:0000313|EMBL:AAX85828.2}.
FT TRANSMEM 697..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..532
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 550..744
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 744..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 644..671
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 749..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 886
FT /evidence="ECO:0000313|EMBL:AAX85828.2"
SQ SEQUENCE 886 AA; 101989 MW; 8557821F5A7CF782 CRC64;
MGCLGNQLLI AILLLSAYGI YCTQYVTVFY GVPAWKNATI PLFCATKNRD TWGTTQCLPD
NGDYSELAIN VTERFDAWNN TVTEQAIEDV WNLFETSIRP CVKLTPLCIT MRCNKTETDK
WGLTGNAATT TTTTTASTTT PKGRADVVNE TSSCVKNNNC TGLEQEPMVS CKFNMTGLKR
DKKKEYNETW YSRDLICEQN TNGSESKCYM NHCNTSIIQE SCDKHYWDAI RFRYCAPPGY
ALLRCNDTNY SGFAPNCSKV VVSSCTRMME TQTSTWFGFN GTRAENRTYI YWHGRSNRTI
ISLNKFYNLT IRCRRPGNKT VLPVTIMSGL VFHSQPINER PKQAWCWFGG SWKKAIQEVK
ETIVKHPRYT GTNDTKKINL TAPRGGDPEV TFMWTNCRGE FLYCKMNWFL NWVEDRDTNG
NIWKQQNRGE QQKRNYVPCH IRQIINTWHK VGKNVYLPPR EGDLTCNSTV TSLIANIDWI
DGNRTNITMS AEVAELYRLE LGDYKLVEIT PIGLAPTNVR RYTTTGASRN KRGVFVLGFL
GFLATAGSAM GAASLTLSAQ SRTLLAGIVQ QQQQLLDVVK RQQELLRLTV WGTKNLQTRV
TAIEKYLKDQ AQLNSWGCAF RQVCHTTVPW PNETLVPDWN NMTWQEWERQ VDDLEANITQ
MLEEAQVQQE KNMYELQKLN SWDIFGNWFD LTSWIRYIQY GVLIVLGVVG LRIVIYIVQM
LARLRQGYRP VFSSPPAYVQ QIPIHKGQEP PTREGEEGDG GDRGGSRSWP WQIEYIHFLI
RQLIRLLTWL FSNCRTCLLR IYQILQPVFQ RLFSILQRIR EVVRTEISYL QYGCRWFQEA
VQAAWRAAGE TLASTWRDLW ETLGRAGRWV LAIPRRIRQG LELTLL
//
