ID Q542T7_MOUSE Unreviewed; 227 AA.
AC Q542T7;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 173.
DE RecName: Full=Ras-related protein Rab-3 {ECO:0000256|RuleBase:RU367096};
GN Name=Rab3c {ECO:0000313|EMBL:AAI14336.1, ECO:0000313|MGI:MGI:1914545};
GN Synonyms=Rab3C {ECO:0000313|EMBL:BAF02851.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC37689.1};
RN [1] {ECO:0000313|EMBL:BAC37689.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37689.1};
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC37689.1}, Spinal ganglion
RC {ECO:0000313|EMBL:BAE37733.1}, and Sympathetic ganglion
RC {ECO:0000313|EMBL:BAE28694.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAC37689.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37689.1};
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC37689.1}, Spinal ganglion
RC {ECO:0000313|EMBL:BAE37733.1}, and Sympathetic ganglion
RC {ECO:0000313|EMBL:BAE28694.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAC37689.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37689.1};
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC37689.1}, Spinal ganglion
RC {ECO:0000313|EMBL:BAE37733.1}, and Sympathetic ganglion
RC {ECO:0000313|EMBL:BAE28694.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAC37689.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37689.1};
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC37689.1}, Spinal ganglion
RC {ECO:0000313|EMBL:BAE37733.1}, and Sympathetic ganglion
RC {ECO:0000313|EMBL:BAE28694.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAF02851.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Balb/c {ECO:0000313|EMBL:BAF02851.1};
RX PubMed=11773082; DOI=10.1074/jbc.M112414200;
RA Kuroda T.S., Fukuda M., Ariga H., Mikoshiba K.;
RT "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2
RT functions as a novel Rab27A binding domain.";
RL J. Biol. Chem. 277:9212-9218(2002).
RN [6] {ECO:0000313|EMBL:BAF02851.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Balb/c {ECO:0000313|EMBL:BAF02851.1};
RX PubMed=11856727; DOI=10.1074/jbc.C200005200;
RA Fukuda M., Kuroda T.S., Mikoshiba K.;
RT "Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
RT implications of a tripartite protein complex for melanosome transport.";
RL J. Biol. Chem. 277:12432-12436(2002).
RN [7] {ECO:0000313|EMBL:BAC37689.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37689.1};
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC37689.1}, Spinal ganglion
RC {ECO:0000313|EMBL:BAE37733.1}, and Sympathetic ganglion
RC {ECO:0000313|EMBL:BAE28694.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [8] {ECO:0000313|EMBL:BAC37689.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37689.1};
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC37689.1};
RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA Hayashizaki Y.;
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:BAF02851.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Balb/c {ECO:0000313|EMBL:BAF02851.1};
RX PubMed=12578829; DOI=10.1074/jbc.M212341200;
RA Fukuda M.;
RT "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2.
RT Identification of a critical determinant of Rab3A/Rab27A recognition by
RT Rim2.";
RL J. Biol. Chem. 278:15373-15380(2003).
RN [10] {ECO:0000313|EMBL:AAI14336.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI14336.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11] {ECO:0000313|EMBL:BAE28694.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE28694.1};
RC TISSUE=Spinal ganglion {ECO:0000313|EMBL:BAE37733.1}, and Sympathetic
RC ganglion {ECO:0000313|EMBL:BAE28694.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:BAC37689.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37689.1};
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC37689.1}, Spinal ganglion
RC {ECO:0000313|EMBL:BAE37733.1}, and Sympathetic ganglion
RC {ECO:0000313|EMBL:BAE28694.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [13] {ECO:0000313|EMBL:BAC37689.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC37689.1};
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC37689.1}, Spinal ganglion
RC {ECO:0000313|EMBL:BAE37733.1}, and Sympathetic ganglion
RC {ECO:0000313|EMBL:BAE28694.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [14] {ECO:0000313|EMBL:BAF02851.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Balb/c {ECO:0000313|EMBL:BAF02851.1};
RX PubMed=16923123; DOI=10.1111/j.1365-2443.2006.00997.x;
RA Itoh T., Satoh M., Kanno E., Fukuda M.;
RT "Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing
RT proteins based on their Rab-binding activity.";
RL Genes Cells 11:1023-1037(2006).
RN [15] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Protein transport. Probably involved in vesicular traffic.
CC {ECO:0000256|RuleBase:RU367096}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367096};
CC Lipid-anchor {ECO:0000256|RuleBase:RU367096}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU367096}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270, ECO:0000256|RuleBase:RU367096}.
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DR EMBL; BC114335; AAI14336.1; -; mRNA.
DR EMBL; AK079574; BAC37689.1; -; mRNA.
DR EMBL; AK148904; BAE28694.1; -; mRNA.
DR EMBL; AK164316; BAE37733.1; -; mRNA.
DR EMBL; AB232589; BAF02851.1; -; mRNA.
DR RefSeq; NP_076341.1; NM_023852.5.
DR AlphaFoldDB; Q542T7; -.
DR SMR; Q542T7; -.
DR MaxQB; Q542T7; -.
DR Antibodypedia; 23602; 141 antibodies from 26 providers.
DR DNASU; 67295; -.
DR GeneID; 67295; -.
DR KEGG; mmu:67295; -.
DR AGR; MGI:1914545; -.
DR CTD; 115827; -.
DR MGI; MGI:1914545; Rab3c.
DR VEuPathDB; HostDB:ENSMUSG00000021700; -.
DR HOGENOM; CLU_041217_10_1_1; -.
DR OMA; PSSQCNC; -.
DR OrthoDB; 8685at2759; -.
DR BioGRID-ORCS; 67295; 1 hit in 78 CRISPR screens.
DR ChiTaRS; Rab3c; mouse.
DR ExpressionAtlas; Q542T7; baseline and differential.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031489; F:myosin V binding; IEA:Ensembl.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd01865; Rab3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR037872; Rab3.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47980; LD44762P; 1.
DR PANTHER; PTHR47980:SF15; RAS-RELATED PROTEIN RAB-3C; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|RuleBase:RU367096};
KW GTP-binding {ECO:0000256|RuleBase:RU367096};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|RuleBase:RU367096};
KW Membrane {ECO:0000256|RuleBase:RU367096};
KW Methylation {ECO:0000256|ARBA:ARBA00022481, ECO:0000256|RuleBase:RU367096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367096};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289, ECO:0000256|RuleBase:RU367096};
KW Protein transport {ECO:0000256|RuleBase:RU367096};
KW Transport {ECO:0000256|RuleBase:RU367096}.
FT REGION 202..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 227 AA; 25872 MW; 179DF4D9B451B7B0 CRC64;
MRHEAPMQMA SAQDARFGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY ADDSFTSAFV
STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY RGAMGFILMY DITNEESFNA
VQDWSTQIKT YSWDNAQVIL AGNKCDMEDE RVVSTERGQR LGEQLGFEFF ETSAKDNINV
KQTFERLVDI ICDKMSESLE TDPAITAAKQ STRLKETPPP PQPNCGC
//
