ID Q54F48_DICDI Unreviewed; 1918 AA.
AC Q54F48;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=RasGTPase-activating protein {ECO:0000313|EMBL:EAL61905.1};
GN ORFNames=DDB_G0291115 {ECO:0000313|EMBL:EAL61905.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL61905.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL61905.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL61905.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GAPVD1 family.
CC {ECO:0000256|ARBA:ARBA00008489}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL61905.1}.
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DR EMBL; AAFI02000175; EAL61905.1; -; Genomic_DNA.
DR RefSeq; XP_635406.1; XM_630314.1.
DR AlphaFoldDB; Q54F48; -.
DR SMR; Q54F48; -.
DR STRING; 44689.Q54F48; -.
DR PaxDb; 44689-DDB0233768; -.
DR GeneID; 8627990; -.
DR KEGG; ddi:DDB_G0291115; -.
DR dictyBase; DDB_G0291115; -.
DR eggNOG; KOG2319; Eukaryota.
DR HOGENOM; CLU_235440_0_0_1; -.
DR InParanoid; Q54F48; -.
DR OMA; QIYNFTF; -.
DR Reactome; R-DDI-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF112; VPS9 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 1124..1336
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1712..1864
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 111..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1006..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 70..97
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1872..1907
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 187..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..457
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1918 AA; 215162 MW; 61B8E0671DD6FEF2 CRC64;
MNVNAMGDII INVFGLVDKR LNRLKGLKAN TFQDYESLLS QYRKIVEILN NAKRLLKKDP
DDQNVISTNL SQLNIRLELV EKEVAFIKNK IDKQEYDNTV ETTIFSPANS QSPILFPSSS
SSSPITTSPT IFSSTLTTTT ITPPQTPLQQ STSSSSSSSG GDQSPIFTSN IIKNDTQIDP
LVNQILESNN NNNNKSTTTT NTTSSESNNS NQQNTPPPLK PFVDDASIIK NNNTNNNNTN
NNNGSFSPNI KKSTKNQAVP PHNVSNNKPP SPQLSSTVSS KAHIVIDKPT GKQQQQQQQT
QKEDSNLTVK QKSEKITQML REQHYLGNKA PSSYNPNEIT FSYKEEMLKN ILNNTDINNL
EEEEVKEKED SFSLSPQLPS KKTTNSSSSP SPSSTPTSPQ HSTITISKEK VNSPKVQLDT
NAPQKTFVEP LQLSDLTTTT TPTTPPTTPP PPPTATTATA NPTVIEIEKI SSPIQVEQVE
KVTKEESKVI IDNQFKGTED IKIKVIKEED IQQQVILKST NDSENSMLKY EETTTTTTTT
TTKRIISNSP LSLSTSSLIN NVEDINSNNN NSSNNNGNDN NNGNNNNNNN TSTPIVLNKT
MISKIQKEET SNSIINNNNS NSNNNKLSQS LSASSLVDTF LLRHRFGTST ESLSISQSIQ
PYFSSESLIS SSLPNSANNI LSNSFNSLSS SNNSNASNNS SSSGNTSITI GGFKSSQQKI
SQKLKLAKQN PIRKQSDTKI GHARSNSNNI IRRSDYDLNN SNSSNNSNSN NNNNNNNNNN
NNISTSLGSL SFSNNNIPFN SNNSNNSNSN IINGNNLSVN DSGESTSSSP YSQTSSSPQT
YANNNNSNSN SNSNNNLNQN VTSEILINSS NKSNSSNSIN SDYNRNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNKLIGQG ERLALLQSLL KSEELTNNAE SKVIDEINKI
TRQKSQELYQ LVWEVRHLDK SIAHILNNRL QISDISDIGL FPDPLKENDN SNNNTPLSNL
NNSNNKNSTS PTLSSSTQSP NIVNKTTKAS SIDQSTVIEL SRELKFTLER LVVLLRTEPS
ILRDTLNRAG YLGSDMDSSF KSSHTDLSQA IVFSLFGNCF TAIDEKLLLL TIKSITEIEF
RISSDKRNFG IHEPFSFTLL STYLNYTYGK PYMISVLKDL VVSIIQDHNL NLENDPQKKA
MLASIGIVDD DDDDSGLPVI DQQILLQQFS GEFLRRVCAL SSSIPYALRW ISKVVIELWR
QHVKQQRKPD FVPSEISKVR DKQEEREFII RLIFENFFIP AIIRPDHYGV LSGLTISQKS
RHNLIQIAKM VLDFLRNPST IPKWLNHHEG MELEQILDEY FIDLITVEEP EHYYHRPIFE
LELGQSLLVS STDLFIILEL IYHNRPNNIS DTNQLTNDQL LFSNSTINSN TTNNTSSAAA
NDYFNHEEEI SLQNEVVEMI KTVQPASQLQ EGMKFLVINV VSKKQASTIN GDNSKIFQTA
SAHSLKLAKA NLTLALSVLN FICGYSQSTN ICELLLMQCG RNRSMELNIL EAQIEETIRS
LWALPETQKQ DDYKSLLDTM FDDFYKRDKK RNLEKQLKVL YLDQLQRHSA QIAAQKKINI
EFLTHQKFRQ FRDKTYARLQ TEFVGSFMSR FNNDTGYCSC VPTLDSSIIC STCSEKSKTI
KSFIQRAKNE MTNSPWWNMS NTTDDEFSIA TNTLERNLLT QIYNFTFNIS KEDLTFSKDL
ISKFSSIDHG LLIAEKYSSQ APWELAQQEI KKINLYKSPQ DKMKCIIDTW NIIFNYTKPF
GSSGPDDFLP IMGYVIIKAR PENILSNIQY IELYSELNDD SEIWFMNLKS SIEIVKEVLK
DAKNKGWRKG IVSSTTQRME NMRKEIKKKE KEKLKSYRMS IVNLETNSVG TPTSPPKL
//
