ID Q54JV1_DICDI Unreviewed; 853 AA.
AC Q54JV1;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=Elongation factor 2 {ECO:0000313|EMBL:EAL63489.1};
GN Name=cinC {ECO:0000313|EMBL:EAL63489.1};
GN ORFNames=DDB_G0287685 {ECO:0000313|EMBL:EAL63489.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL63489.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL63489.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL63489.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL63489.1}.
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DR EMBL; AAFI02000104; EAL63489.1; -; Genomic_DNA.
DR RefSeq; XP_637051.1; XM_631959.1.
DR AlphaFoldDB; Q54JV1; -.
DR SMR; Q54JV1; -.
DR STRING; 44689.Q54JV1; -.
DR PaxDb; 44689-DDB0216236; -.
DR GeneID; 8626305; -.
DR KEGG; ddi:DDB_G0287685; -.
DR dictyBase; DDB_G0287685; cinC.
DR eggNOG; KOG0469; Eukaryota.
DR HOGENOM; CLU_002794_11_2_1; -.
DR InParanoid; Q54JV1; -.
DR OMA; EEDHANI; -.
DR PhylomeDB; Q54JV1; -.
DR Reactome; R-DDI-156902; Peptide chain elongation.
DR Reactome; R-DDI-5358493; Synthesis of diphthamide-EEF2.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8876725; Protein methylation.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IMP:dictyBase.
DR GO; GO:0006414; P:translational elongation; IBA:GO_Central.
DR CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR CDD; cd04096; eEF2_snRNP_like_C; 1.
DR CDD; cd01885; EF2; 1.
DR CDD; cd16268; EF2_II; 1.
DR CDD; cd16261; EF2_snRNP_III; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF10; ELONGATION FACTOR 2; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EAL63489.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EAL63489.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 17..260
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 853 AA; 94569 MW; 6CB27F03191EE592 CRC64;
MVNFTIDQIR SIMDRRENIR NMSVIAHVDH GKTTLTDSLI QRAGIIADKV SGNAGYMSCR
PDEQLRGITI KSSSVSLHFE MPKDEKLPTG CSSHEFLINL IDSPGHVDFS SEVTAALRVT
DGALVVIDCV EGVCVQTETV LRQAMAERIK PVLFVNKVDR FLLELQLNSE DAYLSFTRAI
ESVNVVIGSF GCTGENNEFG NGMMGDINLS PEKGTIAFGS GLHGWGFTIG KFAKLYASKF
GVSEEKLMSR LWGDNYFDQE SKKWKTSNVP SSDDGSGEAK PLQRAFCQFI LDPIYKLTRA
VIDEDQDRID SMLKVLNISL SPEDAELKGK NLIKSIMRKF LPASDAILSM VVSHLPSPLE
AQKYRVSHLY EGPMDDKCAL AIANCDPNGP LMMYVSKMIP TSDKGRFYAF GRVFSGTIRT
GQKVRIMGPD YVPGKKDDLY LKSIQRTVLM MGRKIELLDD CPCGNIIGLV GVDQFLVKSG
TISTEETAHN IRVMKFSVSP VVRVAVQPKN PSELPKLIEG LKILAKADPC VLCITETSGE
HIVAGAGELH LEICLKDLEE DHAGIEIITS DPVVSFCESV SEESKIMCLA KSPNKHNRIY
MKSEPLSSDL TDDIDNGLVA FNQDVKSRAN YLYDKHSWDK NDAVNIWSFG PEYKGPNVLV
NKTKGVQYLH EIKDSMVSAF QWISNEGVLC GEKMRSIRFN VYDVMLHADA IHRGSGQFIP
TTRRVMYASQ LSAQPTLLEP MYLVDISTPE SGISGIYSVL NRRRGVVIGE ERRIGTPLFN
IKAYLPVMES FGLTADLRSS TAGQAFPQCV FDHWSSIGIV GQDKRSTEVA SSIRKRKGLN
PKLPTLEEYN EKL
//
