ID Y5837_DICDI Reviewed; 2200 AA.
AC Q54MP8;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Bromodomain and WD repeat-containing DDB_G0285837;
GN ORFNames=DDB_G0285837;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
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DR EMBL; AAFI02000080; EAL64540.1; -; Genomic_DNA.
DR RefSeq; XP_638029.1; XM_632937.1.
DR AlphaFoldDB; Q54MP8; -.
DR STRING; 44689.Q54MP8; -.
DR PaxDb; 44689-DDB0220685; -.
DR EnsemblProtists; EAL64540; EAL64540; DDB_G0285837.
DR GeneID; 8625294; -.
DR KEGG; ddi:DDB_G0285837; -.
DR dictyBase; DDB_G0285837; -.
DR eggNOG; KOG0644; Eukaryota.
DR HOGENOM; CLU_231215_0_0_1; -.
DR InParanoid; Q54MP8; -.
DR OMA; YPLYIRF; -.
DR Reactome; R-DDI-1266695; Interleukin-7 signaling.
DR Reactome; R-DDI-3247509; Chromatin modifying enzymes.
DR PRO; PR:Q54MP8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05529; Bromo_WDR9_I_like; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.30.30.1040; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR16266:SF17; BRWD3; 1.
DR PANTHER; PTHR16266; WD REPEAT DOMAIN 9; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..2200
FT /note="Bromodomain and WD repeat-containing DDB_G0285837"
FT /id="PRO_0000384445"
FT REPEAT 352..391
FT /note="WD 1"
FT REPEAT 394..433
FT /note="WD 2"
FT REPEAT 442..483
FT /note="WD 3"
FT REPEAT 548..586
FT /note="WD 4"
FT REPEAT 591..630
FT /note="WD 5"
FT REPEAT 653..691
FT /note="WD 6"
FT REPEAT 694..736
FT /note="WD 7"
FT REPEAT 741..780
FT /note="WD 8"
FT DOMAIN 1736..1806
FT /note="Bromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT REGION 137..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..1180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1461..1538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1662..1703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1850..2200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..938
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..997
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1069
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1085
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1162
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1877
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1912..1929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1940..1973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1999..2015
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2028..2043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2128..2147
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2168..2189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2200 AA; 250132 MW; 7F8FB19A11121DCE CRC64;
MENTENKILD KRKEYEKEIY NKEIDQCDDN NINREINYLV YRWLNSQNGI DKNLVTSLFQ
DFNKNDLLPK KVNWLGQQEN FTSNELNEKY KHIQSDHIKS IFSSYRDLAI QHGHFSKLPF
QINTLLGDNA YSMIPKGFND KKDNDNNGDN NLLNKEKIPD NNNNNNSSSS SSSNSNTNKK
KIKVSYLYNR PQVVTPTALQ PENTTNTTTT TTATTTTTTT TTTTNNTNVQ TTPTNTTNTT
LTTPPPQIPI LPTTVPDIDI QQQQQQQQQQ QQQTISKSKN EDINNNNNIL SIQRNRYKSF
TMMRFTENPF DFSIPIPVKL SGQEVISKSL KSTSQLPISF YSNFKNSLIV YGHKAPTYCL
QFDKSGRLYF TGSDDHLVKV WSTYSGRLIA TLRGHLGDIT DMCTSFDNSL LATASNDNVI
RIWNLNSNQY DSIASLTGHD PSVNNTITSI SFLSNPTTRL LVSSDSFGQC KLWNLDKSNH
VISLSLNDNG SQSTINTGNI NDEQIDTEMI TDAEVPILTA TTITTAITTT ATTATATIAT
TTTTTTPGKT NEITGTTMNK GGTLIVASVD SSLKIWSTLF NPPKLVNTLE GHPTTILALQ
YSHGSDAIVS GSYDGTVIIW RHSGGPKWDH VIFNIKNTQR PNQANSHPKK VARSKATFKN
VIWSHDDRFI ITTDYNMIRV WNSLDGSFHL EMAEHTSEVY VTSCHPFDSR LIMSSGYDSQ
VILWSIETGE IIKKFVLQEP GFQCQILDGC FSPDGQKFIV TNSTGKWFMF ELGLGSDINN
LKKLVPNEQY FLTDYHPLIR DANGNVLDEL TQTPPHLMPR AMLVNYQGLP YPDHYNFTDQ
DAIYHLEPYK NTSNYKRDLK IQKEFERREV YTFNQGNPSN IPSHPIVIFV ASEPKPQPKK
IPKKPRRPWD QIEEEIIDDE IIFPSDPSDE DFNPSDASEN SSEDEQQQQH QQQQQDDDDD
DDDDEDYDSD GKKMSTRKKS KIKADKRKKR LLKQSKKFTR RNTSPSKFNE IMNTFDLPED
DDNNSNNNNR KAVSNKRLSN KQKKRYNLIN DGEIEMDDDD QYLNDNILDS DDNDYEHRNR
YDNDEFSGSE SYNGSDGGGG GGDDDSDNSS DNSSENDSSA NGSDSDYSGS KSNKNKRGDK
SKRNKKGKKN VKNKKVQKRG RKKSSTSSSS STSHNQNHLT ASALKKLNDI RKKKEILPVC
PKWLSITSTT SETFYSPQVG DFIFYFYQGH TKYLEKFPPN GIESNLDNKS IVNYILNNNN
INNNNNNNNN NNNNNNNNNN NNNNGVDDQQ INSDDDDSQK IIKKSYQECI IKNLNYFISP
DGTHKVVITL LPVFDQQVPP QNQNDESNFY TVIYHVSDIP DYLVLASKVR KSMLTDWTVP
NKRFRMFYPA SGWYNGTIIE ISDSDPLFPN SPWENIKVLW DDTEEEDRVN YWEIDEKFDD
DQNPQKIKEI KDENENEKVI ENNQQQQQQQ PQQQPQQQPI QNNQQLSINN TNVNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNSLNGGLVD YSGNNNNNNN NNFNYNSNNN LSMSGILDYT
NFNNNNNNFM NYNMYQGNYN GMMMNNNTSN YSYLDPNNSN MYMQTYPQNS TMQNQQQPQL
NNIYYNSQLQ PTNYNYTNNF NTNYSNFNNS SSNIMNYNTN NNFNSPPTAT TSNTTTTTTT
TTETSNNNNN NNNNNNNNNN NNNFKDNILR IKIQYVESIE DEKIENLKKE MKEFLENDEI
TDIYSEPVDL KLYPLYIRFV PHPMDISTII KRLESSYYRS LDAIYFDAKL IMIDAYVYNK
PNTMVAKNSK LVFHRISDIL KEAANYTPSD ILLQSGGSFD SFTLKSMAAD KDDSQLDDED
DSMVSGVTND DDDDDDNLAN NNHGNNKSRN GDGLEGDISI SDSEHDNSKT GKNITRSLLS
PSEDEGGINV NRTPSKRGRK KANATTTTTT TTTTTSSTPS KRLITGRLTR SRSNQSNEES
DDDGFIDDNN SSHQNGGKIL DDSDNDDKNQ NGTDNDYNDD DDDDDNDGDS TNKKRKSIKN
QTEPITKRQR TNRLIFEDED EDDNNQEEDE EDYQEKPKPK PRSKQTTPKV TTPRKRGRKK
IDQSEEEEDE DQSDVNSNNN SDNESGGEDG YSGEDGSESE SNNGGDIDDE EFLNLLEKPK
SKPKGRGRPS FKNNNNNNNI NNNVNLTPSK RGRGRPPKSN
//
