ID Q54N52_DICDI Unreviewed; 1677 AA.
AC Q54N52;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 86.
DE RecName: Full=tRNA/rRNA methyltransferase SpoU type domain-containing protein {ECO:0000259|Pfam:PF00588};
GN ORFNames=DDB_G0285499 {ECO:0000313|EMBL:EAL64587.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL64587.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL64587.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL64587.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL64587.1}.
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DR EMBL; AAFI02000079; EAL64587.1; -; Genomic_DNA.
DR RefSeq; XP_638091.1; XM_632999.1.
DR AlphaFoldDB; Q54N52; -.
DR SMR; Q54N52; -.
DR STRING; 44689.Q54N52; -.
DR PaxDb; 44689-DDB0186533; -.
DR GeneID; 8625137; -.
DR KEGG; ddi:DDB_G0285499; -.
DR dictyBase; DDB_G0285499; -.
DR eggNOG; KOG0839; Eukaryota.
DR HOGENOM; CLU_002618_1_0_1; -.
DR InParanoid; Q54N52; -.
DR OMA; DKCIEIP; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0016423; F:tRNA (guanine) methyltransferase activity; IBA:GO_Central.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR CDD; cd18091; SpoU-like_TRM3-like; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR045330; Trm3/TARBP1.
DR InterPro; IPR044748; Trm3/TARBP1_C.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR12029:SF11; METHYLTRANSFERASE TARBP1-RELATED; 1.
DR PANTHER; PTHR12029; RNA METHYLTRANSFERASE; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 1526..1667
FT /note="tRNA/rRNA methyltransferase SpoU type"
FT /evidence="ECO:0000259|Pfam:PF00588"
FT REGION 1456..1477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1677 AA; 195313 MW; A161001648F07A6C CRC64;
MITTIQQIET FSKSLNKNSI DSDKNEIYDS FLDCILIIDD NNNNNNILEQ LIEKLKSISN
IEYLNSNNIN YHFIKLLLIS IQRIINNNKN DKNNNNNNNN KLYKSLFNTY IEILEISKII
LNQDENHLNK VKILEMVINN IKDTLSLNII ENSFEIVNDL LEKSNLSMIS ILEENDENNI
HFNVLFNLLN KIYNELNNNN NNNNKEILLV INKFRDIFIK NSIELLKKSI DTDIRNGIIS
TLLLPLVNDS IETFNMVKEF AYKMISDPPE SLFVSLVKSE GFKLLSNLFN SFYKNLIFDP
IFWQSIINGL NDINDSLNRK RSSYLLKKSI KISIEKENEI STWGDNWSKY FKWSKEDSEK
LQKLWNTFFL IYESLDDFTI HLIQPVWKEI DSLVIGSSSS SPMSSPSSKE GLDFEWVEIL
FKRCLNHQNP AVIKVLIIDV LNSKQYIPYL PIEFISGTLI QSISNAALYK GVTESTIHVA
TINFFTNYYQ SLSTIKEKSK FIQTIINCLV VNHFQKELLV NIIKFIETIT NQQKLKLTVL
NNEFFPVFLN FFEISIKRLH SNVRNRIYKS IIKSLIYLCD ENNQDYQQLD FNNKSKIIYS
IPLHFHTNLK YNQLLNNWLN SINHNENNNL NNIKLILNNY KIEEKDNLII IDKDIIIKIK
QESFIISRMI LYLNSKEFSE IINEILIEIS KLMIKDSTCK FGLENMSFNK FIILLGSILS
ITELSNQIET LKPLFINTEN FYESFLDFLL NNFKNQQLLN QLQSNYIPTL EIEESLYLIQ
SFIIENILND NNLKSYKIKL NNYLNQIFNN NNIDKNNNNN NNIKIEIQKV IYIQKLFGIF
KERSNISKLF KVEEIEKLID FIFNITIQKP KQQQQEQYDH SIKETLGLWG NINSYFIKTK
WMLIRNLLTC QSEIMKNENQ SLDQSKLLIE KSSNYLEILI DDLSGSNFYC SQPIFHCLTI
LLPIGTKRKD GKIGFNKELF ENCLSYAWTS VMDSGTLTFI GSFIQLAYQH DILSVCINEE
EEEDDEEEIF NHHNLLKEYF YKLLNQSSLV IGLYNLLIMK TTMIWKEYPE IAILYVDEIY
ESLVFGPTRT AGNELHQDDL ELTFHDALIG VPTFVFNLHQ DSICESAKDQ IKFGFGSIPH
KDSFGRAIAT VFLYEMGKLS KSSSSHHMNE NKNKIIEFIN LISMKLLNSN FDKEFLKKKE
YILNTPIHRL KVRIWQSLCI LSKFIQPNSN EQMNEIGSAI VKIFHLFNLP SIRKYVNIFL
VNFMKRHHEI IEIHLIQLLD NLNVRGDILS SIVVTAGYIL LNIENNNQLY QKVFNRILSL
TTSGHQVVKT IASSIIVQIY DTDNKLAEKL SSDSTMLAFL KQLHYFFTNN QQAFKSLEKQ
KQVMDLEKKN QFSSSSFQNV FYDTPVLEQL SPSEIISPGI FEFLLSSNDY SIGNPLEKQL
RDKLLEKSKY LPKVIGVDNG NENDSDDDDE NHKENNIKKL ISNTDDIDEY IDNNPTSYQK
KILPWSNDLD LETRDELVVK KARQSIIIVA SFIDKIPNLA GLARTCEIFN IECLVVSDLK
IRDNKEFQNI TVTAEKWLPM EEVAENDLKQ YLLLKKSQGY SLLGVEQTSS SVLLNKFEFP
QKSVLVLGKE KEGIPTEFIN LLDKCIEIPQ LGIIRSLNVH VSGSLMIWDY FRQQLNK
//
