ID Y3443_DICDI Reviewed; 393 AA.
AC Q54R14;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=SET domain-containing protein DDB_G0283443;
DE EC=2.1.1.-;
GN ORFNames=DDB_G0283443;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable methyltransferase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR EMBL; AAFI02000055; EAL65706.1; -; Genomic_DNA.
DR RefSeq; XP_639077.1; XM_633985.1.
DR AlphaFoldDB; Q54R14; -.
DR SMR; Q54R14; -.
DR PaxDb; 44689-DDB0220713; -.
DR EnsemblProtists; EAL65706; EAL65706; DDB_G0283443.
DR GeneID; 8624102; -.
DR KEGG; ddi:DDB_G0283443; -.
DR dictyBase; DDB_G0283443; -.
DR eggNOG; KOG2084; Eukaryota.
DR HOGENOM; CLU_702894_0_0_1; -.
DR InParanoid; Q54R14; -.
DR OMA; VLECNFC; -.
DR PhylomeDB; Q54R14; -.
DR PRO; PR:Q54R14; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd20071; SET_SMYD; 1.
DR Gene3D; 1.10.220.160; -; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR12197; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD; 1.
DR PANTHER; PTHR12197:SF304; SET AND MYND DOMAIN-CONTAINING PROTEIN DDB_G0273589-RELATED; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 3: Inferred from homology;
KW Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..393
FT /note="SET domain-containing protein DDB_G0283443"
FT /id="PRO_0000389439"
FT DOMAIN 17..312
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ SEQUENCE 393 AA; 46230 MW; E00A6AAC05945923 CRC64;
MENNNNNNKN DNEINFKKIE INETLESGKF IESKIDMKLG ELIIKVQSPM CFSFHKHLVN
QFCFNCFSNS HEINNAKFNK FKVDINKNYI IRCNNCKLIY FCSDECFEKV MSIESFQDST
STNIHTPLEC LILSNYHDQT ISPKINTLHD QTENRMIINY LSKIAYSTNN NNKFKLLLIE
MNQLIGDFNN DNNNQTLSLN EIKNIKNKSF NLRKLFNNFF FNIDKVIIEE LYAKSQRNSF
GLWKNSDECF GLSMYGNQTI YNNNNDKDDN ISISYFNHSC FPNCVRVQEN QSISIYSLIP
IKKGDELSIS YIDIRMSKND RLLHLKEIYY FECKCKRCTL PPLSNLSLEI EKTIENYTCK
NQSIKCTGIL YLPPFNKIQR ICNFCHWKEP INN
//
