ID Q54YF3_DICDI Unreviewed; 876 AA.
AC Q54YF3;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 18-MAR-2008, sequence version 2.
DT 24-JAN-2024, entry version 117.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EAL68306.2};
GN ORFNames=DDB_G0278267 {ECO:0000313|EMBL:EAL68306.2};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL68306.2, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL68306.2, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL68306.2,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL68306.2}.
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DR EMBL; AAFI02000023; EAL68306.2; -; Genomic_DNA.
DR RefSeq; XP_642249.2; XM_637157.2.
DR AlphaFoldDB; Q54YF3; -.
DR SMR; Q54YF3; -.
DR PaxDb; 44689-DDB0233659; -.
DR EnsemblProtists; EAL68306; EAL68306; DDB_G0278267.
DR GeneID; 8621458; -.
DR KEGG; ddi:DDB_G0278267; -.
DR dictyBase; DDB_G0278267; -.
DR eggNOG; KOG0705; Eukaryota.
DR eggNOG; KOG4226; Eukaryota.
DR HOGENOM; CLU_328300_0_0_1; -.
DR InParanoid; Q54YF3; -.
DR OMA; TWKLANP; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0022607; P:cellular component assembly; IEA:UniProt.
DR CDD; cd08833; ArfGap_GIT; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR PANTHER; PTHR45819:SF5; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 311..372
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 744..857
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 25..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 99305 MW; 11A9C9E8D372B3F5 CRC64;
MVESPKVRRT SSSQRLYNNN IKWVTVRPST DNNNNNSSQK RSSNINIFTG ESHQPEEFEI
ESHGSSSSIG TSLDEYNQHY LQAQQHQHQH QQHKHIFGSS FVDLSGFTPN SFEFKYPSVG
NSPSVTVSSS LSLSSSIMGT SSGKSKLSLD TWKLANPDST ITIKKIKTSP RGSKEDIFNA
DSEQQPQSSP QLQLPLHPQP QPQSQSHITS NANAPQSSFN KVQPQGQEPQ SVVNRTRSRQ
LSKPPVFIQQ FQNHHHQQQQ QQQQHQLSTS QSSASSLISH TQRRLSRAKQ HQVEFNNNGN
GNSNNGNGEK VHLQHALVLY SFDADLEEEL NLIKDTTIIV VEQCADGWWK GRHLDSTKVA
TFPANYVKLI PSLLPQNNNN TTTTLPSSSS STNTTTTTTN NNNTPTSIDQ QIQLLNKKRS
ESLSNGNNNN NNNNNNNNNN NNNNSCFKDD PNIFFPTFNN NLSSSNSSRV NTDNGSMSFS
KSSRSIRKNS LSSSFSSSSN ASASILFQIK VYVPPFHEHT IILIAGGDTL KDLLEKLGRK
KKMLFNEFKC KLRYYDSNID LPLDTLISSL KDSDRNPLKL FMLSFDYINK FNNITTNIQL
SNYFIISYNN IKNNNNNNNH NNNSILQKQW VIFDNQSIQI FNSHTDQQPI RIIGLKYSSV
KHSNSSPNCF IVKTPFSLFK FTHDYFNIVN QWIDTIEQSR EYQDGNPNLK RKQKKLIIKS
SDSLSNTTSS LSFSGHFPPP IDRKQQILEI RNKEINRVCV DCCSKDPEWA SISLGCFLCD
TCCGIHQKVL PNYSEVLSVI LDDQWEDIHI NIFDKIGNNI SNQYWEYNLL SKIVKPNSLA
YEKENFIVSK YKKKEFTPSV NIPCPISIFN NEFSKQ
//
