ID Q557I6_DICDI Unreviewed; 552 AA.
AC Q557I6; Q8SSQ6;
DT 02-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 02-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=MEK1 interacting protein 1 {ECO:0000313|EMBL:EAL70722.1};
GN Name=mip1-2 {ECO:0000313|EMBL:EAL70722.1};
GN Synonyms=mip1-1 {ECO:0000313|EMBL:EAL70654.1};
GN ORFNames=DDB_G0273399 {ECO:0000313|EMBL:EAL70654.1}, DDB_G0273535
GN {ECO:0000313|EMBL:EAL70722.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL70722.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL70722.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL70722.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=12097910; DOI=10.1038/nature00847;
RG Dictyostelium Genome Sequencing Consortium;
RA Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000313|EMBL:EAL70722.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL70722.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3] {ECO:0000313|EMBL:EAL70722.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL70722.1};
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.-A., Sucgang R.,
RA Song J., Cox E.C., Tunggal B., Szafranski K., Konfortov B.A.,
RA Farbrother P., Bankier A.T., Lehmann R., Hamlin N., Xu Q., Davies R.,
RA Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.,
RA Davis P., Nie X., Kerhornou A., Hemphill L., Bason N., Berriman M.,
RA Desany B., Churcher C., Cooper J., van Driessche N., Cronin A.,
RA Goodhead I., Muzny D., Hall N., Harper D., Lindsay R., Hauser H., James K.,
RA Quiles M., Buchrieser C., Wardroper A., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Price C., Ma J., Quail M.,
RA Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Weinstock G.,
RA Sharp S., Just E., Shaulsky G., Simmonds M., Tivey A., White B., Walker D.,
RA Woodward J., Winckler T., Schleicher M., Rosenthal A., Rivero F.,
RA Chisholm R.L., Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J.,
RA Dear P.H., Noegel A.A., Barrell B., Kuspa A.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL70722.1}.
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DR EMBL; AAFI02000010; EAL70654.1; -; Genomic_DNA.
DR EMBL; AAFI02000010; EAL70722.1; -; Genomic_DNA.
DR RefSeq; XP_644602.1; XM_639510.1.
DR RefSeq; XP_644649.1; XM_639557.1.
DR AlphaFoldDB; Q557I6; -.
DR STRING; 44689.Q557I6; -.
DR PaxDb; 44689-DDB0191344; -.
DR GeneID; 8618966; -.
DR GeneID; 8619011; -.
DR KEGG; ddi:DDB_G0273399; -.
DR KEGG; ddi:DDB_G0273535; -.
DR dictyBase; DDB_G0273399; mip1-1.
DR dictyBase; DDB_G0273535; mip1-2.
DR eggNOG; KOG2177; Eukaryota.
DR HOGENOM; CLU_493855_0_0_1; -.
DR Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:dictyBase.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:dictyBase.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR GO; GO:0030010; P:establishment of cell polarity; IMP:dictyBase.
DR GO; GO:0051457; P:maintenance of protein location in nucleus; IMP:dictyBase.
DR GO; GO:0016567; P:protein ubiquitination; IDA:dictyBase.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047134; RNF4.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23041:SF78; E3 UBIQUITIN-PROTEIN LIGASE RNF4; 1.
DR PANTHER; PTHR23041; RING FINGER DOMAIN-CONTAINING; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 500..538
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 20..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..184
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..364
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 63029 MW; AF5BC9A62F65A10B CRC64;
MDSQTSQDIP EILNDIFELM DRQIDEENKQ QKDDKNKTIA HGTSQLVQHE NPQEDFAFGV
KNPIQQNEEE KKNEEEKQNE EVKQNEEEKQ NEEVKQNVEE KQENRENEQH NEENEQQNGE
QNKEEEQQSQ QSQQSQQSQQ SQQIDLNIKK EGEKQNQRQS SRQVVIIDLS DDDEDDEDDD
GENDNDKPTP ISNTETTETS TTTTTTTTNV NNQNNNQDKE VVDLTLSPPQ SPVLVLTATR
LANNNNNHNN DRNNNSNNNS NNRFLNRQAN DFTFFRNNSF FNSRTQHQPP PPPSQQQFPI
VLNIFNNHSG SAVGNGPIGN NGNGGNSLKK RKHYHNFDTD DDDDDDDDDD DDEDDDDEDD
DDDDVHFDRR NQFPISPEDL FDENIDISFG FGGRDRNSDS SDDSFFRPTN RQSLVGTNRS
AVRNNNNSNN NNTTATASIQ TTKPEVIHIL EKQGNSSLSS ISENSELWKL QKEMEKENES
KKAIDTQSNG GDKKSKNLEC PICFEDTKPY VSTLCGHIFC SDCIVNALKK KKSCPVCNAK
LHGKKPYHPI YI
//
