ID Q559R8_DICDI Unreviewed; 1540 AA.
AC Q559R8;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 112.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=DDB_G0272450 {ECO:0000313|EMBL:EAL71377.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL71377.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL71377.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL71377.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=12097910; DOI=10.1038/nature00847;
RG Dictyostelium Genome Sequencing Consortium;
RA Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000313|EMBL:EAL71377.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL71377.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL71377.1}.
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DR EMBL; AAFI02000008; EAL71377.1; -; Genomic_DNA.
DR RefSeq; XP_645266.1; XM_640174.1.
DR AlphaFoldDB; Q559R8; -.
DR SMR; Q559R8; -.
DR PaxDb; 44689-DDB0217012; -.
DR GeneID; 8618432; -.
DR KEGG; ddi:DDB_G0272450; -.
DR dictyBase; DDB_G0272450; -.
DR eggNOG; KOG1225; Eukaryota.
DR HOGENOM; CLU_003793_0_0_1; -.
DR InParanoid; Q559R8; -.
DR OMA; CSGWGTC; -.
DR PhylomeDB; Q559R8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24032:SF20; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24032; EGF-LIKE DOMAIN-CONTAINING PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF07974; EGF_2; 7.
DR Pfam; PF01833; TIG; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 14.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 8.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1488..1512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 631..664
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 706..740
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 779..813
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 852..886
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 925..959
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 998..1031
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1070..1103
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1187..1220
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1376..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 635..645
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 654..663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 730..739
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 803..812
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 876..885
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 949..958
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1002..1012
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1021..1030
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1074..1084
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1093..1102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1191..1201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1210..1219
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1540 AA; 167321 MW; 02E21234AA9E9F1E CRC64;
MKYYINNLFL ILVLIITLLI GINNAIIRTE YNLAVGILNN HGNNTIQPIY SDKEFVGKEN
ILCDGISFKC FGSYITEIIL HSNIDDINPM PNEFVGFFNL TSITLYDFMI DNSFFSNATN
FMNTNNYNQD YQGVTSVKII NPRPIFGSIS TQVHLPSVFI GFNTTLNYVQ YLEGLTNIVN
LSNGGGTSYP RSLELFSKNL PDFSGFTNIK KFKLDLQNQF DENSFDRFRN YTGIEEIEIT
TRDFNSMTNQ YYLFEGDNIM TVKKLKLKIG IQKTPQRLTF KNYPDLTDVE IITSRDFSIV
LTNSFQFKNV SSLVSNFKLS GSNFTNIESA FSVLSKVVNI NLSDNLIGGF LPEIHNLNFT
KNLDISNNNI VGTIPQSYCS ISNTNFSNNG FTGLIPNCFI CFMKNNLENN FLGNYFTNKD
SANSYCGAIE PSLRMGTGKI YMEGRNLGFN GSNIVTIPNL QWEVEIPSTR FSASYTYSTN
QLFSIFFQNP GVTLFARVIQ NNPTVSMVTV YPNYTVIFDG SDFTYDKTLI SINISNYYCN
IISSTFYRIE CVISNAIEMT NSNSEIIIAD NSLATTNQLG TTTTTAVDDS LVLGLNMKTY
LTVRNLAGWQ TLGVHLTVDY DPNLQNGTQI KIFQCLNGCS NHGLCISRTG SCDCYEGYGG
IDCSSIVVSL ICPSNDSSLI CSGFGICDKK TGVCACGTGR TGNDCSETAC PISDCSDHGY
CDTSIGKCNC DSSHQGAGCE MDLVSCPTSN KAICSGWGTC NNQTGICTCD ANRVGSDCSG
ISCPVPNCNG NGNCDTTVGQ CSCDPSHQGA NCEMNFVSCP TPNRSVCSGW GTCNNQTGIC
TCDANRVGSD CSGIACPVSD CSGHGYCDTT IGQCNCDSSH QGAGCEMDLI LCPTSNKATC
SGWGTCNYQT GICTCDANRV GSDCSGISCP VSDCSGHGYC DTTVGQCNCD SSHQGAGCEM
DLVSCPTSNK AICSGWGTCN NQTGSCTCDI GRVGADCSGI RCQSDCNGHG ICDTTIGKCN
CDSSHQGESC ELNLITCPSK NNIECSGLGS CNNQTGICSC NDGTTYSDCS GILCSVNCLN
NGVCNYDIGK CKCTPNWKSD NCTTPIHYLS SIDPCTTSGG QVTIYGWFSN QHINLTVTIG
GVECVDPIET ENTIICELPA GSGTKDVNIT QNGSSFIGKN KFQYISTVFK CPKDCSNHGK
CDTSIGVCTC SSDYSGFDCS SLKPPTTSSS STTSTTIGGE TKNQEIPVSK TEVNVETGAA
SISNQDVNYE ISIISIVELD YNGEVVKTND LKKKWDITID PSTKYIYQFS QQIDQFSNIT
LIIEEIVNSS KKYTFAGMNL EIDQGGLKIS VSIKNYQYES ALNTLQLRFL SSAGETSNLD
SEEDNSCNQH ESESDTSNID PNLTLNYISI SKNSKILSGR FINKVVSDGR STFMSSEIVK
DLSSSSTIVV GLNLPHCSNE CFIDPDFSVL VSPNFESSCG NSETKKNWVI PVAVVVPVVC
VSLLTLGAIL IYRKHRYSIR LFTMKKSFSV KQRFKLRSFK
//
