ID Q55FY5_DICDI Unreviewed; 1088 AA.
AC Q55FY5;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 116.
DE RecName: Full=Minichromosome loss protein Mcl1 middle region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DDB_G0267904 {ECO:0000313|EMBL:EAL73405.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL73405.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL73405.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL73405.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL73405.1}.
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DR EMBL; AAFI02000003; EAL73405.1; -; Genomic_DNA.
DR RefSeq; XP_647398.1; XM_642306.1.
DR AlphaFoldDB; Q55FY5; -.
DR SMR; Q55FY5; -.
DR STRING; 44689.Q55FY5; -.
DR PaxDb; 44689-DDB0189629; -.
DR GeneID; 8616205; -.
DR KEGG; ddi:DDB_G0267904; -.
DR dictyBase; DDB_G0267904; -.
DR eggNOG; KOG1274; Eukaryota.
DR HOGENOM; CLU_285046_0_0_1; -.
DR InParanoid; Q55FY5; -.
DR OMA; EIVITIA; -.
DR PhylomeDB; Q55FY5; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0043596; C:nuclear replication fork; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR048591; Ctf4-like_C.
DR InterPro; IPR022100; Mcl1_mid.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19932; WD REPEAT AND HMG-BOX DNA BINDING PROTEIN; 1.
DR PANTHER; PTHR19932:SF10; WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1; 1.
DR Pfam; PF20946; Ctf4_C; 1.
DR Pfam; PF12341; Mcl1_mid; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 152..184
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 268..300
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 466..837
FT /note="Minichromosome loss protein Mcl1 middle region"
FT /evidence="ECO:0000259|Pfam:PF12341"
FT DOMAIN 850..942
FT /note="DNA polymerase alpha-binding protein Ctf4-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF20946"
FT REGION 364..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1088 AA; 121813 MW; DFA9D3DEC4F73D88 CRC64;
MVVKKQKKSE PIIKAKPTDL KIIDSGNNNK NQGLLKYHPE INKLLFCYPK SNQIYYQNED
KNILLNTHGD GSKIVTSIDL GVYHKCASSC EDNTINIFST SNNGNVDVQT ISVPSTPNCI
KFNPTQSFLA VGSLNNIKSI SMTNVREHHL IKDAHKGEVI TLQYSNDGNY LASIGEDSKL
KIWESGKFEL WGEEPSPIHT ITLDCTKETL KKIGISWRPS PLSKRGTSDS SNRFELTIPT
YSSNTIKTLQ FNSKDFQNKW KSYIFDDSDG HIKEVTNVQW SSGGEYLAST SLDCYLLIWD
CGVDDLSDST LPTEPIVRYK HHCPIISFSW SPYSSNSISF FDSKGNLYQY SNFVGSDGDD
IDTKLSLEDD EPSFDFNDDD FSFDENDNNK KKNEEQQEEG DDNDNNNDDD DDGDKIKKPK
ILQRNGINLN DKSKVDNDYN EMDDHQDNIS VRSNGNDEFN DYNQESFQIG STYQFVNNNP
KTRRLKTKRY YLAYNMLGKI IKREETKGNG ETSSIEIDFH DTSFHKKVVF PDPNQCLRIA
SLNSCGAIFA TKFNQEELDE YQEKQEEIML KRLEEEEAIA NGTSLSSSLG GGSSGSGGPS
QRQLELQQQY ATKPKSTLTF KSFDSNNGTG DWSYIDKDGI SGVAVSKNYI ISCSENGIVR
IFSLGGIQLN LFSLPGDLVT MNTHADQLAI VYHKSISGRN GTQYMNVWWI NLVNGKQFYH
DTLPLSPFSK LSWIGFSDEG LLTSMDTGGM IRQLSNGWIQ SVSDMTSTTP TTASTSTTFL
QWIPITDLTK CDKPHSQELY TYWVIGLGKK DIYSIFCCEY PLIKQQTHNY VKIELPLLTN
NGGPSSISNE REFVKSKFQL SSYLNYSIAS NTFEESVATK QIAEIDSTII RLFDFYAQQG
HYKKCMDLCG LLHLKKSLSI VFALSNKMGL SWLSKKIVEF IENFKPLNLN PQIISSSSSQ
ISSSLSSSLS SSQNSSQTTT TTTTTSPTVQ IDSPPKSTPT PKTTTTTTTT PQRVLNNTFD
SDIFSTGGAE ESPPPKSTST SNIVKSPKTK KIPFQVKSNS SIKSPDNASK KRKDTPTSNQ
PSKISKFK
//
