ID Q568U8_DANRE Unreviewed; 247 AA.
AC Q568U8;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 130.
DE SubName: Full=Empty spiracles homeobox 2 {ECO:0000313|EMBL:AAH92713.1};
DE SubName: Full=Emx2 protein {ECO:0000313|EMBL:AAI65103.1};
DE SubName: Full=Homeobox protein EMX2 {ECO:0000313|RefSeq:NP_571355.2};
GN Name=emx2 {ECO:0000313|EMBL:AAH92713.1,
GN ECO:0000313|ZFIN:ZDB-GENE-990415-54};
GN Synonyms=fk69b03 {ECO:0000313|RefSeq:NP_571355.2}, wu:fk69b03
GN {ECO:0000313|RefSeq:NP_571355.2}, zgc:109855
GN {ECO:0000313|RefSeq:NP_571355.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH92713.1};
RN [1] {ECO:0000313|RefSeq:NP_571355.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9655819;
RA Kobayashi M., Toyama R., Takeda H., Dawid I.B., Kawakami K.;
RT "Overexpression of the forebrain-specific homeobox gene six3 induces
RT rostral forebrain enlargement in zebrafish.";
RL Development 125:2973-2982(1998).
RN [2] {ECO:0000313|RefSeq:NP_571355.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12070082;
RA Mathieu J., Barth A., Rosa F.M., Wilson S.W., Peyrieras N.;
RT "Distinct and cooperative roles for Nodal and Hedgehog signals during
RT hypothalamic development.";
RL Development 129:3055-3065(2002).
RN [3] {ECO:0000313|RefSeq:NP_571355.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11992730; DOI=10.1016/S0378-1119(01)00828-9;
RA Minguillon C., Ferrier D.E., Cebrian C., Garcia-Fernandez J.;
RT "Gene duplications in the prototypical cephalochordate amphioxus.";
RL Gene 287:121-128(2002).
RN [4] {ECO:0000313|RefSeq:NP_571355.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12617801; DOI=10.1016/S1567-133X(02)00062-5;
RA Kawahara A., Dawid I.B.;
RT "Developmental expression of zebrafish emx1 during early embryogenesis.";
RL Gene Expr. Patterns 2:201-206(2002).
RN [5] {ECO:0000313|RefSeq:NP_571355.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15533813;
RA Plouhinec J.L., Granier C., Le Mentec C., Lawson K.A., Saberan-Djoneidi D.,
RA Aghion J., Shi D.L., Collignon J., Mazan S.;
RT "Identification of the mammalian Not gene via a phylogenomic approach.";
RL Gene Expr. Patterns 5:11-22(2004).
RN [6] {ECO:0000313|EMBL:AAH92713.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium {ECO:0000313|EMBL:AAH92713.1}, and PCR
RC rescue {ECO:0000313|EMBL:AAI65103.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|RefSeq:NP_571355.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28705894;
RA Askary A., Xu P., Barske L., Bay M., Bump P., Balczerski B.,
RA Bonaguidi M.A., Crump J.G.;
RT "Genome-wide analysis of facial skeletal regionalization in zebrafish.";
RL Development 144:2994-3005(2017).
RN [9] {ECO:0000313|RefSeq:NP_571355.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28266911;
RA Jiang T., Kindt K., Wu D.K.;
RT "Transcription factor Emx2 controls stereociliary bundle orientation of
RT sensory hair cells.";
RL Elife 6:e23661-e23661(2017).
RN [10] {ECO:0000313|RefSeq:NP_571355.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28096348;
RA Rabinowitz J.S., Robitaille A.M., Wang Y., Ray C.A., Thummel R., Gu H.,
RA Djukovic D., Raftery D., Berndt J.D., Moon R.T.;
RT "Transcriptomic, proteomic, and metabolomic landscape of positional memory
RT in the caudal fin of zebrafish.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:E717-E726(2017).
RN [11] {ECO:0000313|RefSeq:NP_571355.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29671737;
RA Ji Y.R., Warrier S., Jiang T., Wu D.K., Kindt K.S.;
RT "Directional selectivity of afferent neurons in zebrafish neuromasts is
RT regulated by Emx2 in presynaptic hair cells.";
RL Elife 7:e35796-e35796(2018).
RN [12] {ECO:0000313|RefSeq:NP_571355.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30024872;
RA Lozano-Ortega M., Valera G., Xiao Y., Faucherre A., Lopez-Schier H.;
RT "Hair cell identity establishes labeled lines of directional
RT mechanosensation.";
RL PLoS Biol. 16:e2004404-e2004404(2018).
RN [13] {ECO:0000313|RefSeq:NP_571355.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; BC092713; AAH92713.1; -; mRNA.
DR EMBL; BC165103; AAI65103.1; -; mRNA.
DR RefSeq; NP_571355.2; NM_131280.2.
DR GeneID; 30537; -.
DR KEGG; dre:30537; -.
DR AGR; ZFIN:ZDB-GENE-990415-54; -.
DR CTD; 2018; -.
DR ZFIN; ZDB-GENE-990415-54; emx2.
DR OrthoDB; 903523at2759; -.
DR Proteomes; UP000000437; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IEP:ZFIN.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060121; P:vestibular receptor cell stereocilium organization; IMP:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24339; HOMEOBOX PROTEIN EMX-RELATED; 1.
DR PANTHER; PTHR24339:SF25; HOMEOBOX PROTEIN EMX2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 147..207
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 149..208
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 207..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 247 AA; 28012 MW; 9D892112A25188AC CRC64;
MFQPTPKRCF TIESLVAKDN PLPSSRSEEP IRPAALSYAN SSQMNPFLNG FHSSGRGVYS
NPGLVFAEAV SHPPNSAVPV HSVPPPHALA AHPLSSSHSP HPLFASQQRD PSTFYPWLIH
RYRYLGHRFQ GNETSPESFL LHNALARKPK RIRTAFSPSQ LLRLEHAFEK NHYVVGAERK
QLAHSLSLTE TQVKVWFQNR RTKFKRQKLE EEGSDSQQKK KGTHHINRWR LATKQGSPEE
IDVTSDD
//
