ID Q56NI1_BRANA Unreviewed; 466 AA.
AC Q56NI1;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 08-NOV-2023, entry version 65.
DE RecName: Full=3-ketoacyl-CoA synthase {ECO:0000256|PIRNR:PIRNR036417};
DE EC=2.3.1.- {ECO:0000256|PIRNR:PIRNR036417};
GN Name=FAE1 {ECO:0000313|EMBL:AAX58614.1};
OS Brassica napus (Rape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=3708 {ECO:0000313|EMBL:AAX58614.1};
RN [1] {ECO:0000313|EMBL:AAX58614.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18075728; DOI=10.1007/s00122-007-0685-z;
RA Wu G., Wu Y., Xiao L., Li X., Lu C.;
RT "Zero erucic acid trait of rapeseed (Brassica napus L.) results from a
RT deletion of four base pairs in the fatty acid elongase 1 gene.";
RL Theor. Appl. Genet. 116:491-499(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC EC=2.3.1.199; Evidence={ECO:0000256|ARBA:ARBA00001906};
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|PIRNR:PIRNR036417}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|PIRNR:PIRNR036417}.
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DR EMBL; AY888037; AAX58614.1; -; Genomic_DNA.
DR AlphaFoldDB; Q56NI1; -.
DR UniPathway; UPA00094; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009922; F:fatty acid elongase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR012392; 3-ktacl-CoA_syn.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR31561; 3-KETOACYL-COA SYNTHASE; 1.
DR PANTHER; PTHR31561:SF88; 3-KETOACYL-COA SYNTHASE 18; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR PIRSF; PIRSF036417; 3-ktacl-CoA_syn; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|PIRNR:PIRNR036417};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|PIRNR:PIRNR036417};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..368
FT /note="FAE"
FT /evidence="ECO:0000259|Pfam:PF08392"
FT DOMAIN 388..446
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 223
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 302
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 387
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 391
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 420
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 424
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
SQ SEQUENCE 466 AA; 52035 MW; 8037037521715DC5 CRC64;
MTSINVKLLY HYVITNLFNL CFFPLTAIVA GKAYRLTIDD LHHLYYSYLQ HNLITIAPLF
AFTVFGSVLY IATRPKPVYL VEYSCYLPPT HCRSSISKVM DIFYQVRKAD PSRNGTCDDS
SWLDFLRKIQ ERSGLGDETH GPEGLLQVPP RKTFAAAREE TEQVIIGALE NLFKNTNVNP
KDIGILVVNS SMFNPTPSLS AMVVNTFKLR SNVRSFNLGG MGCSAGVIAI DLAKDLLHVH
KNTYALVVST ENITYNIYAG DNRSMMVSNC LFRVGGAAIL LSNKPRDRRR SKYELVHTVR
THTGADDKSF RCVQQGDDEN GKTGVSLSKD ITDVAGRTVK KNIATLGPLI LPLSEKLLFF
VTFMGKKLFK DKIKHYYVPD FKLAIDHFCI HAGGKAVIDV LEKNLGLAPI DVEASRSTLH
RFGNTSSSSI WYELAYIEAK GRMKKGNKVW QIALGALSVT VQFGWL
//