ID Q56VC6_ORYLA Unreviewed; 306 AA.
AC Q56VC6;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 6 {ECO:0000256|ARBA:ARBA00015761};
DE AltName: Full=Apo-1 antigen {ECO:0000256|ARBA:ARBA00032338};
DE AltName: Full=Apoptosis-mediating surface antigen FAS {ECO:0000256|ARBA:ARBA00032502};
DE AltName: Full=FASLG receptor {ECO:0000256|ARBA:ARBA00030181};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|EMBL:AAS91707.1};
RN [1] {ECO:0000313|EMBL:AAS91707.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HNI {ECO:0000313|EMBL:AAS91707.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AAS91707.1};
RX PubMed=17540041; DOI=10.1186/1471-2164-8-141;
RA Sakamaki K., Nozaki M., Kominami K., Satou Y.;
RT "The evolutionary conservation of the core components necessary for the
RT extrinsic apoptotic signaling pathway, in Medaka fish.";
RL BMC Genomics 8:141-141(2007).
CC -!- SUBCELLULAR LOCATION: Membrane raft {ECO:0000256|ARBA:ARBA00004285}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; AY518736; AAS91707.1; -; mRNA.
DR RefSeq; NP_001098259.1; NM_001104789.1.
DR AlphaFoldDB; Q56VC6; -.
DR GeneID; 101172757; -.
DR CTD; 355; -.
DR OrthoDB; 24515at2759; -.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08316; Death_FAS_TNFRSF6; 1.
DR CDD; cd13423; TNFRSF6_teleost; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR008063; Fas_rcpt.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR033998; TNFRSF6_death.
DR InterPro; IPR034055; TNFRSF6_N_teleost.
DR PANTHER; PTHR46874; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; 1.
DR PANTHER; PTHR46874:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01680; TNFACTORR6.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 2: Evidence at transcript level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..306
FT /note="Tumor necrosis factor receptor superfamily member 6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004251141"
FT TRANSMEM 160..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 69..113
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 69..113
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 114..154
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 114..154
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 229..294
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 306 AA; 33389 MW; 40AE0B0AF15FB781 CRC64;
MATTGLKNVW IYFLLLAIGT LVPSIEVPNA GDCADGSYTH DGKTCCLCAP GQKVLKHCTD
SPTNGECGFC EEGKTYREEP NSQTTCELCD SCSHPNANLE VVERCTTSRN AKCGCQKGYY
CDSEKGSCVV CQSCDICEST GIKIACNGTS NTVCNESQGI SAGAIAGIVI VIILAILVTG
GVIWWKKTRQ LSDGAEPDSE ELEYLNEVDI KPHLADIAQI LGWKDMLYIA RKSKMLDTTI
DSCQLNHPND TEESTVELLQ KWSEIKGRTG VRSLVQMLNA SRKQDKKERI LNLIKNDTNN
ECSNPV
//
