ID   Q57B58_BRUAB            Unreviewed;       498 AA.
AC   Q57B58;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE            EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN   Name=mmsA {ECO:0000313|EMBL:AAX75126.1};
GN   OrderedLocusNames=BruAb1_1811 {ECO:0000313|EMBL:AAX75126.1};
OS   Brucella abortus biovar 1 (strain 9-941).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=262698 {ECO:0000313|EMBL:AAX75126.1, ECO:0000313|Proteomes:UP000000540};
RN   [1] {ECO:0000313|EMBL:AAX75126.1, ECO:0000313|Proteomes:UP000000540}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9-941 {ECO:0000313|EMBL:AAX75126.1,
RC   ECO:0000313|Proteomes:UP000000540};
RX   PubMed=15805518; DOI=10.1128/JB.187.8.2715-2726.2005;
RA   Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z.,
RA   Li L.L., Kapur V., Alt D.P., Olsen S.C.;
RT   "Completion of the genome sequence of Brucella abortus and comparison to
RT   the highly similar genomes of Brucella melitensis and Brucella suis.";
RL   J. Bacteriol. 187:2715-2726(2005).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017223; AAX75126.1; -; Genomic_DNA.
DR   RefSeq; WP_002966975.1; NC_006932.1.
DR   AlphaFoldDB; Q57B58; -.
DR   EnsemblBacteria; AAX75126; AAX75126; BruAb1_1811.
DR   GeneID; 58775182; -.
DR   KEGG; bmb:BruAb1_1811; -.
DR   HOGENOM; CLU_005391_1_10_5; -.
DR   Proteomes; UP000000540; Chromosome I.
DR   GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:InterPro.
DR   CDD; cd07085; ALDH_F6_MMSDH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR010061; MeMal-semiAld_DH.
DR   NCBIfam; TIGR01722; MMSDH; 1.
DR   PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          14..478
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
SQ   SEQUENCE   498 AA;  53530 MW;  8900E8EAC3E5C140 CRC64;
     MRNIGHFIGG KHVAGKSGRT ADIFQPLDGT VQGKVALATK EEVRAAVENA KAAQPAWAAT
     NPQRRVRVLR KFIELVEAEY DSLAELLARE HGKTIADARG DIQRGLEVVE VCLGAAHMLK
     GEFTDNAGTG IDTYSMRQPL GVVAGITPFN FPAMIPLWKA GPAIACGNAF ILKPSERDPG
     VPMRLAELFQ EAGLPAGIFN VVNGDKESVD ALLDDPDVQA IGFVGSTPIA QYIYGRGCAN
     GKRVQCFGGA KNHLLIMPDA DMDQTVDALI GAGYGSAGER CMAISVAVPV GEDTANRLME
     KLIPRVESLK IGPSTDNSAD YGPLVTKAAL DRVRGYVDLG VEEGAKLVVD GRNFKMQGYE
     NGFYMGGCLF DHVTPDMRIY KEEIFGPVLS IVRAKNYEEA LALPSDHEFG NGVAIFTRDG
     DAARDFASRV QVGMVGINVP IPVPIAYYTF GGWKASGFGD LNQHGPDAFR FYTKTKTVTS
     RWPSGVKDGA EFVIPTMK
//