ID Q581W0_TRYB2 Unreviewed; 1495 AA.
AC Q581W0; D6XKV9;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 106.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN Name=Tb08.26N11.820 {ECO:0000313|EMBL:AAZ12989.1};
GN ORFNames=Tb927.8.2220 {ECO:0000313|EMBL:AAX79443.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX79443.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAX79443.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79443.1};
RA El-Sayed N.M., Khalak H., Adams M.D.;
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAZ12989.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ12989.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [3] {ECO:0000313|EMBL:AAZ12989.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ12989.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [4] {ECO:0000313|EMBL:AAX79443.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79443.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAZ12989.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ12989.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AC091701; AAX79443.1; -; Genomic_DNA.
DR EMBL; CP000071; AAZ12989.1; -; Genomic_DNA.
DR RefSeq; XP_847055.1; XM_841962.1.
DR AlphaFoldDB; Q581W0; -.
DR STRING; 185431.Q581W0; -.
DR PaxDb; 5691-AAZ12989; -.
DR GeneID; 3659207; -.
DR KEGG; tbr:Tb927.8.2220; -.
DR VEuPathDB; TriTrypDB:Tb927.8.2220; -.
DR eggNOG; ENOG502RXRX; Eukaryota.
DR InParanoid; Q581W0; -.
DR OrthoDB; 5383069at2759; -.
DR Proteomes; UP000008524; Chromosome 8.
DR GO; GO:0008270; F:zinc ion binding; ISM:GeneDB.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1328..1368
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 34..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1163..1197
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 35..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..989
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1495 AA; 162838 MW; 2F9F265A408E64A4 CRC64;
MDTTNGGGNC NVRGLGGSLI RLLELYPVKQ VAADEGTTET EQGMSKEEVN SPSPVKSQRE
GNMKRNRVVN SHPPKQDVLD CAEVGQYLIA TGSKDKVSAM QANVLEVRSA LSAPSPVAIP
NANQCPSNVL LTPLVPTGEY VPSYDTKEQI KYSLVGEPGT RCQSPLPLFR GSRVDDQVRE
ATMFFSNLLA ARQHECADQE MGPLHGGSGA PYQLPAFYDI LSRTIGTSRS REAGQESREA
GGYLPLISPV HAGATSSGRL FRGVRHSSAR LRSNTPLGND FCVGGVCGLM GRRLIGVPVH
DRRLNAHLMS SWEKGVKARL PARKAFKAIK SSCWWRLAGS REGLLLAARL VNLDADVYES
LLTRWVDGIR HSYTRFVTVN VDAFVSEDIG QNLITGPRGR KLGPVLPFSG SEAVMNSLFP
GDVELSDMLG VARQLGYLQM GGALCEDDVA RVLQCDTRTI QRELRRLMLQ RSGGTVQPLG
VLPIFEGKGC RLYEPNTAIR QISRAILRAR RRAAAEEAKK KGRKIRFSLL PDVTTCSRVL
QRRLQKIAAS RPGDVQALLE QLGVLADAVN SGGLESIKSC PEVLSRLQEI IADMPPDVQA
SLQQLGFLTD DSGRISVSSD GRPRVSRGRS RKAANVVPSN VHKFLKKLDN ISRTITGGGP
PESDGSAELL QRGLQEIAAS RPGDVQALLE QLGVLADAVN SGGLESIKSC PEALSRLQEI
AASMPPDVRA SLQQLGFLPD GDGVIGVENL CEVAKRQQEL SSGAPHPSEG MRGATTEGLK
SPTEGASFSV SARRKIRRRT PKVVKMAAAD EKGPIVHNVP PSSVKDQGEG PAARDKSALS
ASSPLGDEAT AWPGNHAAFA VDESEADAKD QSWEDTAFGT KKGLLKKRRR LRSKTSSELE
TLTDDDAERA LFADKHASFG KRSSPGRFRG RTSPMGVLGI ESFPTSGDAD DPLSGFVASQ
LKESYSGPQE GEETDDYEYT PRERSRMNRS RAQPVFSEWD TEQLPPQLPS GAKDPRLLSQ
TASILVFPNS GRRGSRAASV ASRTACSDTE SVRGVEDPWE LSSMFSNDDN ELALFLATFP
DEERHVQLRR EAHRVLDDIN AGSKVLEEYA IKLKVRPSSM GPSAGAGGGM QPCEQEWTER
DEQMEKRMLE CRVDIQSMVE RFKAEAQEEY ADLWRTLQEL RKRVEVQEAL LEETKLDINR
LSYPMEGEDT DAFALRLTRE VNAFAEQNKL DPQQLKDLTT AKQDREAAVR SFLESFARTR
GRRGGVSVGC QCTPKDLGYI DTEVLELNKQ MEDLQYHARG LLNSIKLVVI SMGNVLSFHS
ALELESTCKR CFCIFEEPRT LWPCGHSFCL HCLTQMISKG GELICDECGT LCLVGYTPNF
AIEMVAGYQL MWINSAEDDV SEDSLCSSPS PKSSLTSSNS KGSKPSSHAG QKRRTVEKVL
AGLLKDLLST QGSGKATRKT ERKSKKPSKS TSGELPLPPL KGGLPPSAAT KVQCA
//
