ID Q583R5_TRYB2 Unreviewed; 639 AA.
AC Q583R5; D6XI02;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Ubiquitin carboxyl-terminal hydrolase, putative {ECO:0000313|EMBL:AAX80972.1};
DE EC=3.1.2.15 {ECO:0000313|EMBL:AAX80972.1};
GN Name=Tb06.5F5.130 {ECO:0000313|EMBL:AAZ11831.1};
GN ORFNames=Tb927.6.2690 {ECO:0000313|EMBL:AAX80972.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX80972.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAX80972.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX80972.1};
RA El-Sayed N.M., Khalak H., Adams M.D.;
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAZ11831.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11831.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [3] {ECO:0000313|EMBL:AAZ11831.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11831.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [4] {ECO:0000313|EMBL:AAX80972.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX80972.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAZ11831.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11831.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AC084047; AAX80972.1; -; Genomic_DNA.
DR EMBL; CP000069; AAZ11831.1; -; Genomic_DNA.
DR RefSeq; XP_845390.1; XM_840297.1.
DR AlphaFoldDB; Q583R5; -.
DR STRING; 185431.Q583R5; -.
DR PaxDb; 5691-AAZ11831; -.
DR GeneID; 3657904; -.
DR KEGG; tbr:Tb927.6.2690; -.
DR VEuPathDB; TriTrypDB:Tb927.6.2690; -.
DR eggNOG; KOG4598; Eukaryota.
DR InParanoid; Q583R5; -.
DR OMA; CARENHE; -.
DR OrthoDB; 119839at2759; -.
DR Proteomes; UP000008524; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR CDD; cd02257; Peptidase_C19; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF888; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:AAX80972.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT DOMAIN 247..637
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 639 AA; 70409 MW; EF95EB9DC4F83425 CRC64;
MRSVADGIGY AGSAEAAADL GSIKSCDNDP QLWMCLRCGL YCCGVHRKSH YDNSRMSGVG
TDDKINGGHR IFFAVKPRWG TDVNSPAVGA PLPTVTINLC QVESPERRTV TMNNLKVSKV
SFEKVGTYGI ISCVECHEDP IKLPVRNSLP CLGVDLITLC ENVAKVLHCV ERNISLAPDY
DEGSFGAPRA RGVLDSGIAT DTRRQNSNYE TYSYVETNKQ ANSRAATSSN SRCVRARAGT
LVEACISGFE NRRNTCYFNS VLQCILQCNT FIDFMIRQKF TGSHTLVHHM SEMIGFMKSG
PCAGDRQGIV DGLARALMGS LSEIVPMFGD GDQQDSQELF ITLINGIADE LDKGKSEEEK
KGSQRVPFEG MLCTTVTCRG CKNQVKRDEV FMALSIPVTN SVEDSLEKLF ERSTLNGDSQ
YACEVCFNKL SPAEQTKKNN DIRAENEARK LRKKANAEAK SLNCLYQDAD VETSIGRFNG
SLALHLLRFK CDDRGVYKVP GAVSFPKRLN LSKYIVGSAA SGCGDTKMPQ TIVQTNVNTH
RSVSRPSNSL VHVSGGDGCT SSVEESTDNR RSQLDLELVG IISHVGSLHG GHYVAHVRSH
TKPSMWFYCD DEEIYTVDES SVFEREQGVY MLFYDQLYH
//
