ID Q583T9_TRYB2 Unreviewed; 734 AA.
AC Q583T9; D6XHE9;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Serine/threonine protein phosphatase, putative {ECO:0000313|EMBL:AAX80468.1};
GN Name=Tb06.3D8.430 {ECO:0000313|EMBL:AAZ11628.1};
GN ORFNames=Tb927.6.640 {ECO:0000313|EMBL:AAX80468.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX80468.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAX80468.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX80468.1};
RA El-Sayed N.M., Khalak H., Adams M.D.;
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAZ11628.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11628.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [3] {ECO:0000313|EMBL:AAZ11628.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11628.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [4] {ECO:0000313|EMBL:AAX80468.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX80468.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAZ11628.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11628.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AC084046; AAX80468.1; -; Genomic_DNA.
DR EMBL; CP000069; AAZ11628.1; -; Genomic_DNA.
DR RefSeq; XP_845187.1; XM_840094.1.
DR AlphaFoldDB; Q583T9; -.
DR SMR; Q583T9; -.
DR STRING; 185431.Q583T9; -.
DR PaxDb; 5691-AAZ11628; -.
DR GeneID; 3657694; -.
DR KEGG; tbr:Tb927.6.640; -.
DR VEuPathDB; TriTrypDB:Tb927.6.640; -.
DR eggNOG; ENOG502S28V; Eukaryota.
DR InParanoid; Q583T9; -.
DR OMA; GKDCLIH; -.
DR OrthoDB; 152010at2759; -.
DR BRENDA; 3.1.3.16; 6520.
DR Proteomes; UP000008524; Chromosome 6.
DR GO; GO:0051286; C:cell tip; IDA:GeneDB.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0010494; C:cytoplasmic stress granule; IDA:GeneDB.
DR GO; GO:0000298; F:endopolyphosphatase activity; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IDA:GeneDB.
DR GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; ISM:GeneDB.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IMP:GeneDB.
DR GO; GO:0006798; P:polyphosphate catabolic process; IBA:GO_Central.
DR GO; GO:0006470; P:protein dephosphorylation; ISM:GeneDB.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR PANTHER; PTHR42850:SF12; PROTEIN PHOSPHATASE, PUTATIVE-RELATED; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT DOMAIN 272..452
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT REGION 62..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 79107 MW; 4410D47D85AE869E CRC64;
MTSSTLLEKL SSLKLSEGAR VGGRTFRQGV MSPGTIANVT TTATTNINNT NVASAFASLM
EKRQPTGSPA ENEGPLRGLI IGSDGSGNNN NSSSNNNNNN NNNNSRSMKH SSNNSSTNSG
NDKPIETQAP HRSGVEGSAG KAARKLRSSP RTHQLPDEMR EKTSHISAVP RSVALALASA
SVGVTEQPSV TVEQLMRAAP SANVSSVTSP PRCVPTLPVE PMVVVDREGG PDAVRLATLV
SGDPSNPKLI DPIDNVNAHK PIIRTVPPCD YRYIIVGDVH GCPEQLEELL LKVEFQQGKD
CLIHVGDLVN KGPDSLAVVQ LVQAKGAIGV LGNHDFTLLN CIARVKGKAL SQQEEVDPVM
RLASTFPQGC EDYIRSLPHI LRIPQYNVIV VHAGLNVENS LEKQNVHEIM HLRRLERYTE
SSNNNNNNCG GKQQRNEKQR LRAVVKGSRG QPWGELWTGP ECVVFGHDAR AGLQELPFAY
GIDTGCVYGG QLTAVVYGRD SPKGKLVSVT GLPKDANERR GLPPPAADVY EKYAEELERL
ILRPTPRATP AIIGYMQKPT FLSAPPPGSP AASTGSVINN SLRPDSCCSL PAASPSLSAR
ATVRSSGVEQ ETLLSLLRAG EIRAVMTLMR LPAYESMWLN LLCSEVEGCT ESFWIPFVKG
VLDGLLNTRQ NGEGDDYVED LLQLVLEACD EFCSVREMAI PQLRKLQQRA EGGDFALPKA
TVKMLKLTVS PQNA
//
