ID Q58CQ4_BOVIN Unreviewed; 605 AA.
AC Q58CQ4;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 03-MAY-2023, entry version 73.
DE SubName: Full=Hook homolog 2 {ECO:0000313|EMBL:AAX46740.1};
GN Name=HOOK2 {ECO:0000313|EMBL:AAX46740.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAX46740.1};
RN [1] {ECO:0000313|EMBL:AAX46740.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX46740.1};
RX PubMed=11282978; DOI=10.1101/gr.170101;
RA Smith T.P., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T., Casas E.,
RA Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L., Heaton M.P.,
RA Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G., Holt I.,
RA Karamycheva S., Liang F., Quackenbush J., Keele J.W.;
RT "Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries
RT and construction of a gene index for cattle.";
RL Genome Res. 11:626-630(2001).
RN [2] {ECO:0000313|EMBL:AAX46740.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX46740.1};
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the hook family.
CC {ECO:0000256|ARBA:ARBA00006946}.
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DR EMBL; BT021893; AAX46740.1; -; mRNA.
DR RefSeq; NP_001019726.1; NM_001024555.1.
DR AlphaFoldDB; Q58CQ4; -.
DR GeneID; 526516; -.
DR KEGG; bta:526516; -.
DR CTD; 29911; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR008636; Hook_C.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR PANTHER; PTHR18947:SF37; PROTEIN HOOK HOMOLOG 2; 1.
DR Pfam; PF05622; HOOK; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701}.
FT DOMAIN 6..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT COILED 180..427
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 475..530
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 605 AA; 69313 MW; A96F5C8B1F9BAA44 CRC64;
MSMDKEELCG SLLTWLQTFN VPPPCTSPQD LSSGLAVAFV LNQIDPSWFN EAWLQGISED
PGPNRRLKVS NLKAILQSLV EYSQDVLGHP ILEQHLPDVS LIGEFSDPEE LGKLLQLVLG
CAISCEKKQE HIQRIMTLEE SVQHVVMEAI QELMTKDTSD SLSPETYGNF DSQSRRYYFL
SEEADEGDEL RQRCLDLERQ LVLLSEEKQS LAQENSVLRE RVGRPEDEGA SGLTAKKLLL
LQTQLEQLQE ENFRLESGRE DERMRCVELE REVAELQQRN QALTSLAQEA QALKDEMDEL
RQSSERAGQL EATLNSCRRR LGELRELRRQ VRQLEECNAS HAERTRQLEE ELRRAGSLRA
QLEAQRRQVQ ELQGKRQEEA MKAEKWLFEC RNLEEKYEPV TKEKERLLAE RDSLREANEE
LRCAQMQPRG LAQADPSLDP TSPAVGNLAA EILPAELRET LLRLQLENKR LCQQEAADRE
RQEELQRHLE EANRARHGLE TQHRLNQQQL SELRAQVEDL QKALQEQGGK TEDVSAHLLP
AWPSPVPTTN PLLSPHCCLM PREVHSKYLG LRVPLPTLTR QEGWDLWTPH PHTHPAPLLS
SSQSC
//
