ID Q58D51_BOVIN Unreviewed; 540 AA.
AC Q58D51;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Arylsulfatase K {ECO:0000256|ARBA:ARBA00035710};
DE EC=3.1.6.1 {ECO:0000256|ARBA:ARBA00035026};
DE EC=3.1.6.18 {ECO:0000256|ARBA:ARBA00035675};
DE AltName: Full=Glucuronate-2-sulfatase {ECO:0000256|ARBA:ARBA00035719};
GN Name=DKFZp313G1735 {ECO:0000313|EMBL:AAX46593.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAX46593.1};
RN [1] {ECO:0000313|EMBL:AAX46593.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX46593.1};
RX PubMed=11282978; DOI=10.1101/gr.170101;
RA Smith T.P., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T., Casas E.,
RA Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L., Heaton M.P.,
RA Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G., Holt I.,
RA Karamycheva S., Liang F., Quackenbush J., Keele J.W.;
RT "Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries
RT and construction of a gene index for cattle.";
RL Genome Res. 11:626-630(2001).
RN [2] {ECO:0000313|EMBL:AAX46593.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX46593.1};
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-
CC glucuronate residues of chondroitin sulfate, heparin and heparitin
CC sulfate.; EC=3.1.6.18; Evidence={ECO:0000256|ARBA:ARBA00035590};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aryl sulfate + H2O = a phenol + H(+) + sulfate;
CC Xref=Rhea:RHEA:17261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16189, ChEBI:CHEBI:33853, ChEBI:CHEBI:140317; EC=3.1.6.1;
CC Evidence={ECO:0000256|ARBA:ARBA00034984};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; BT021746; AAX46593.1; -; mRNA.
DR RefSeq; NP_001030477.1; NM_001035400.1.
DR GeneID; 533618; -.
DR KEGG; bta:533618; -.
DR CTD; 153642; -.
DR OrthoDB; 5488719at2759; -.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16171; ARSK; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR047892; ARSK.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR46615; ARYLSULFATASE K; 1.
DR PANTHER; PTHR46615:SF1; ARYLSULFATASE K; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..540
FT /note="Arylsulfatase K"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012429559"
FT DOMAIN 36..374
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
SQ SEQUENCE 540 AA; 61345 MW; 22DCAEE7B32E95F0 CRC64;
MLLLWVSVVA ASALAAPAPG ADGQRRGAIQ AWPDAPNVLL VVSDSFDGRL TFYPGSQVVK
LPFINFMKAH GTSFLNAYTN SPICCPSRAA MWSGLFTHLT ESWNNFKGLD PNYTTWMDVM
EKHGYRTQKF GKLDYTSGHH SISNRVEAWT RDVAFLLRQE GRPMVNLAPK KTKVRVMQVD
WKNTDRAVNW LRKEASNSTQ PFVLYLGLNL PHPYPSPSSG ENFGSSTFHT SRYWLKKVSY
DAIKIPKWSP LSEMHPVDYY SSYTKNCTGK FTEKEIKNIR AFYYAMCAET DAMLGEIILA
LRQLGLLQKT IVIYTSDHGE LAMEHRQFYK MSMYEASSHV PLLIMGPGIQ ANLQVSSVVS
LVDIYPTMLD IAGIPLPQNL SGYSLLPSSS EMFKNEQKFK NLHPPWILSE FHGCNVNAST
YMLRTNQWKY IAYSDGASVL PQLFDLSSDP DELTNIAAKF PEVTSSLDQK LRSIINYPKV
SASVHQYNKE QFIKWKQSIG XNYSTVIANL RWHQDWLKKP KKYENAIDQW LKSHSEAKTI
//