ID Q58DK0_BOVIN Unreviewed; 937 AA.
AC Q58DK0;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 24-JAN-2024, entry version 100.
DE SubName: Full=Integrin alpha 2b {ECO:0000313|EMBL:AAX46444.1};
GN Name=ITGA2B {ECO:0000313|EMBL:AAX46444.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAX46444.1};
RN [1] {ECO:0000313|EMBL:AAX46444.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX46444.1};
RX PubMed=11282978; DOI=10.1101/gr.170101;
RA Smith T.P., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T., Casas E.,
RA Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L., Heaton M.P.,
RA Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G., Holt I.,
RA Karamycheva S., Liang F., Quackenbush J., Keele J.W.;
RT "Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries
RT and construction of a gene index for cattle.";
RL Genome Res. 11:626-630(2001).
RN [2] {ECO:0000313|EMBL:AAX46444.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX46444.1};
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; BT021597; AAX46444.1; -; mRNA.
DR RefSeq; NP_001014929.1; NM_001014929.1.
DR GeneID; 515011; -.
DR KEGG; bta:515011; -.
DR CTD; 3674; -.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF73; INTEGRIN ALPHA-IIB; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 896..918
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 11..71
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 281..346
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 348..407
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 410..471
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 456..601
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 682..886
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 758..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 937 AA; 103245 MW; 1C14F55A40500E1E CRC64;
MPPTWALNLD SVQFTVYTGP NGSHFGFSLD FYKNSNGSVY VVVGAPRTLG HSEEETGGVF
LCPWKAEGGQ CISLPFDLYD ETRSIGTQTF QTFKAGQGLG ASVVSWRDSI VACAPWQHWN
VLDRNEEEAQ KTPVGGCFVA HLQNGDRTEY SPCRDNKMSQ FYERNHFRDD RRYCEAGFSS
VVTXAGELVL GAPGGYYFVS LLARAPIADI ISSYRPSTLL WHVPTQFTYD QSHLQYYDGY
RGYSVAVGNF DGNPNTTEYV FGAPTWSWTL GAVEILDSYH QMLHRLHGEQ MASYFGHSVA
VTDVNGDGRH DLLVGAPLYM ESRADRKLAE VGRVYLFLQT RGARMLGAPN LLLTGTQLYG
RFGSAIAPLG DLNRDGYNDV AVAAPCGGPN GQGQVLVYLG QSEGLNPSPS QVLDSPFPTG
SGFGFSLRGA TDIDDNGYPD LLVGAYGASK VVVYRAQPVV MVTVQLMVQD SLNPAVKTCV
LSQTKTPVSC FNIQMCVGAT GHNIPEKLHL NAELQLDRQK PRQGRRVLLL DSQQAGTILN
LDLRGRHNPN CSTATAFLRD EADFRDKLSP IVLSFSVSLP PEKDGGAPAL VLHGNTHVQE
QGFERLICNQ KKENETKVVL CELGNPMKSN AQIEVMMWVS VEKLEEAGEQ VSFLLQIRSK
NSQNPNSEMV ELDVPVRAVA HVELRGNSFP ASLVVAAEEG NGQNSSDSWG PKVEHTYELH
NNGPGAVSGL RLNLYLPSQS QPSDLLYILD IHPQGGLQCA SQPSPNPLQL EWRLPTPSPS
PAHHKRDRRQ AVLPEEKQPS RLQDPILVSC DSAPCTVVQC ELQEMARGQR VMVTVLALLS
RSILQERPLD QFVLQSHAWF NVSSFPYSVP ALSLPSGEAL VQTQLLRVSE EREIPMWWVL
VGVLGGLLLL TFLILAMWKV GFFKRNRPPL EEDDEEE
//
