ID Q58SB3_DROSI Unreviewed; 326 AA.
AC Q58SB3;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Tehao {ECO:0000313|EMBL:AAX37959.1};
DE Flags: Fragment;
GN Name=Tehao {ECO:0000313|EMBL:AAX37959.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:AAX37959.1};
RN [1] {ECO:0000313|EMBL:AAX37959.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TX-11 {ECO:0000313|EMBL:AAX37959.1};
RX PubMed=15654108; DOI=10.1534/genetics.104.035337;
RA Schlenke T.A., Begun D.J.;
RT "Linkage disequilibrium and recent selection at three immunity receptor
RT loci in Drosophila simulans.";
RL Genetics 169:2013-2022(2005).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; AY864581; AAX37959.1; -; Genomic_DNA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13676; TIR_2; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 188..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 240..326
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAX37959.1"
FT NON_TER 326
FT /evidence="ECO:0000313|EMBL:AAX37959.1"
SQ SEQUENCE 326 AA; 36898 MW; E4ECA5AE126ECBB7 CRC64;
AVVCTNDEAC QYKXAEWQCD PRCICWVQRS IGSLIVDCRG TSLGXLPDLP RTTLLSTVLK
VGNNSLTSLP AVSEHSGYAN VSGLFLXDNN LTTLGSGDQL PENLTHLDVR GNQIQSLSEE
FILFLQEPNN TMTLSLSGNP ISCGCESLSL LFFVRTNPQR VRDIADIVCT KQKKAFQQME
AFELCPSYVL LISCVVGGLV IVICLLTVFY LMFQQELKIW LYNNNLCLWW VSEEELDKDK
TYDAFISYSH KDEELISKLL PKLESGPHPF RLCLHDRDWL VGDCIPEQIV RTVDDSKRVI
IVLSQHFIDS VWARMEFRIA YQATLQ
//
