ID Q58XB1_9HIV1 Unreviewed; 352 AA.
AC Q58XB1;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAX54715.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAX54715.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAX54715.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A15-00131243 {ECO:0000313|EMBL:AAX54715.1};
RX PubMed=17919099; DOI=10.1089/aid.2006.0256;
RA Holguin A., De Arellano E.R., Soriano V.;
RT "Amino acid conservation in the gp41 transmembrane protein and natural
RT polymorphisms associated with enfuvirtide resistance across HIV-1
RT variants.";
RL AIDS Res. Hum. Retroviruses 23:1067-1074(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY751012; AAX54715.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:AAX54715.1};
KW Virion {ECO:0000313|EMBL:AAX54715.1}.
FT DOMAIN 19..210
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 209..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAX54715.1"
FT NON_TER 352
FT /evidence="ECO:0000313|EMBL:AAX54715.1"
SQ SEQUENCE 352 AA; 40435 MW; 47261809862B59D0 CRC64;
AVGLGAVFIG FLGAAGSTMG AASITLTVQA RQLLSGIVQQ QSNLLKAIEA QQHLLRLTVW
GIKQLQARVL ALERYLVDQQ HLGIWGCSGK LICTTTVPWN SSWSNKTLND IWENMTWLQW
DREISNYTEE IYRLIEASQN QQEKNEQDLL ALDKWASLWN WFNIAKWLWY IKLFIMIVGG
LIGLRIVFTV LNMINRVRQG YSPLSFQTLH HHQREPDRPE RIEEGGGEQD RDRSVRLVSS
FLALVWDDLR NLCLFSYHRL RDFVLIAVRG VELLGHSSLK GLRLGWEALK YLWNLLLYWG
QELKNSAINL LDTVAIAVAN WTDRVIEIGQ GAGRAIRNIP RRIRQGLERL LL
//
