ID Q59FH1_HUMAN Unreviewed; 3587 AA.
AC Q59FH1;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Transformation/transcription domain-associated protein variant {ECO:0000313|EMBL:BAD92726.1};
DE Flags: Fragment;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92726.1};
RN [1] {ECO:0000313|EMBL:BAD92726.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BAD92726.1};
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RT "Homo sapiens protein coding cDNA.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR EMBL; AB209489; BAD92726.1; -; mRNA.
DR PeptideAtlas; Q59FH1; -.
DR GO; GO:0048584; P:positive regulation of response to stimulus; IEA:UniProt.
DR GO; GO:0080135; P:regulation of cellular response to stress; IEA:UniProt.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 2413..2985
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3228..3551
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3555..3587
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 205..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1744..1765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2264..2299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2995..3017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..239
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1749..1765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2997..3016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAD92726.1"
SQ SEQUENCE 3587 AA; 405817 MW; 87DFA9102B5995D5 CRC64;
TLSFLAYIIR IYQELVTKYS QQMVKGMLQL LSNCPAETAH LRKELLIAAK HILTTELRNQ
FIPCMDKLFD ESILIGSGYT ARETLRPLAY STLADLVHHV RQHLPLSDLS LAVQLFAKNI
DDESLPSSIQ TMSCKLLLNL VDCIRSKSEQ ESGNGRDVLM RMLEVFVLKF HTIARYQLSA
IFKKCKPQSE LGAVEAALPG VPTAPAAPGP APSPAPVPAP PPPPPPPPPA TPVTPAPVPP
FEKQGEKDKE DKQTFQVTDC RSLVKTLVCG VKTITWGITS CKAPGEAQFI PNKQLQPKET
QIYIKLVKYA MQALDIYQVQ IAGNGQTYIR VANCQTVRMK EEKEVLEHFA GVFTMMNPLT
FKEIFQTTVP YMVERISKNY ALQIVANSFL ANPTTSALFA TILVEYLLDR LPEMGSNVEL
SNLYLKLFKL VFGSVSLFAA ENEQMLKPHL HKIVNSSMEL AQTAKEPYNY FLLLRALFRS
IGGGSHDLLY QEFLPLLPNL LQGLNMLQSG LHKQHMKDLF VELCLTVPVR LSSLLPYLPM
LMDPLVSALN GSQTLVSQGL RTLELCVDNL QPDFLYDHIQ PVRAELMQAL WRTLRNPADS
ISHVAYRVLG KFGGSNRKML KESQKLHYVV TEVQGPSITV EFSDCKASLQ LPMEKAIETA
LDCLKSANTE PYYRRQAWEV IKCFLVAMMS LEDNKHALYQ LLAHPNFTEK TIPNVIISHR
YKAQDTPARK TFEQALTGAF MSAVIKDLRP SALPFVASLI RHYTMVAVAQ QCGPFLLPCY
QVGSQPSTAM FHSEENGSKG MDPLVLIDAI AICMAYEEKE LCKIGEVALA VIFDVASIIL
GSKERACQLP LFSYIVERLC ACCYEQAWYA KLGGVVSIKF LMERLPLTWV LQNQQTFLKA
LLFVMMDLTG EVSNGAVAMA KTTLEQLLMR CATPLKDEER AEEIVAAQEK SFHHVTHDLV
REVTSPNSTV RKQAMHSLQV LAQVTGKSVT VIMEPHKEVL QDMVPPKKHL LRHQPANAQI
GLMEGNTFCT TLQPRLFTMD LNVVEHKVFY TELLNLCEAE DSALTKLPCY KSLPSLVPLR
IAALNALAAC NYLPQSREKI IAALFKALNS TNSELQEAGE ACMRKFLEGA TIEVDQIHTH
MRPLLMMLGD YRSLTLNVVN RLTSVTRLFP NSFNDKFCDQ MMQHLRKWME VVVITHKGGQ
RSDGNESISE CGRCPLSPFC QFEPAMEGVE EMKICSAIIN LFHLIPAAPQ TLVKPLLEVV
MKTERAMLIE AGSPFREPLI KFLTRHPSQT VELFMMEATL NDPQWSRMFM SFLKHKDARP
LRDVLAANPN RFITLLLPGG AQTAVRPGSP STSTMRLDLQ FQAIKIISII VKNDDSWLAS
QHSLVSQLRR VWVSENFQER HRKENMAATN WKEPKLLAYC LLNYCKRNYG DIELLFQLLR
AFTGRFLCNM TFLKEYMEEE IPKNYSIAQK RALFFRFVDF NDPNFGDELK AKVLQHILNP
AFLYSFEKGE GEQLLGPPNP EGDNPESITS VFITKVLDPE KQADMLDSLR IYLLQYATLL
VEHAPHHIHD NNKNRNSKLR RLMTFAWPCL LSKACVDPAC KYSGHLLLAH IIAKFAIHKK
IVLQVFHSLL KAHAMEARAI VRQAMAILTP AVPARMEDGH QMLTHWTRKI IVEEGHTVPQ
LVHILHLIVQ HFKVYYPVRH HLVQHMVSAM QRLGFTPSVT IEQRRLAVDL SEVVIKWELQ
RIKDQQPDSD MDPNSSGEGV NSVSSSIKRG LSVDSAQEVK RFRTATGAIS AVFGRSQSLP
GADSLLAKPI DKQHTDTVVN FLIRVACQVN DNTNTAGSPG EVLSRRCVNL LKTALRPDMW
PKSELKLQWF DKLLMTVEQP NQVNYGNICT GLEVLSFLLT VLQSPAILSS FKPLQRGIAA
CMTCGNTKVL RAVHSLLSRL MSIFPTEPST SSVASKYEEL ECLYAAVGKV IYEGLTNYEK
ATNANPSQLF GTLMILKSAC SNNPSYIDRL ISVFMRSLQK MVREHLNPQA ASGSTEATSG
TSELVMLSLE LVKTRLAVMS MEMRKNFIQA ILTSLIEKSP DAKILRAVVK IVEEWVKNNS
LMAANQTPTL REKSILLVKM MTYIEKRFPE DLELNAQFLD LVNYVYRDET LSGSELTAKL
EPAFLSGLRC AQPLIRAKFF EVFDNSMKRR VYERLLYVTC SQNWEAMGNH FWIKQCIELL
LAVCEKSTPI GTSCQGAMLP SITNVINLAD SHDRAAFAMV THVKQEPRER ENSESKEEDV
EIDIELAPGD QTSTPKTKEL SEKDIGNQLH MLTNRHDKFL DTLREVKTGA LLSAFVQLCH
ISTTLAEKTW VQLFPRLWKI LSDRQQHALA GEISPFLCSG SHQVQRDCQP SALNCFVEAM
SQCVPPIPIR PCVLKYLGKT HNLWFRSTLM LEHQAFEKGL SLQIKPKQTT EFYEQESITP
PQQEILDSLA ELYSLLQEED MWAGLWQKRC KYSETATAIA YEQHGFFEQA QESYEKAMDK
AKKEHERSNA SPAIFPEYQL WEDHWIRCSK ELNQWEALTE YGQSKGHINP YLVLECAWRV
SNWTAMKEAL VQVEVSCPKE MAWKVNMYRG YLAICHPEEQ QLSFIERLVE MASSLAIREW
RRLPHVVSHV HTPLLQAAQQ IIELQEAAQI NAGLQPTNLG RNNSLHDMKT VVKTWRNRLP
IVSDDLSHWS SIFMWRQHHY QAIVTAYENS SQHDPSSNNA MLGVHASASA IIQYGKIARK
QGLVNVALDI LSRIHTIPTV PIVDCFQKIR QQVKCYLQLA GVMGKNECMQ GLEVIESTNL
KYFTKEMTAE FYALKGMFLA QINKSEEANK AFSAAVQMHD VLVKAWAMWG DYLENIFVKE
RQLHLGVSAI TCYLHACRHQ NESKSRKYLA KVLWLLSFDD DKNTLADAVD KYCIGVPPIQ
WLAWIPQLLT CLVGSEGKLL LNLISQVGRV YPQAVYFPIR TLYLTLKIEQ RERYKSDSGQ
QQPSSVGNQS HSASDPGPIR ATAPMWRCSR IMHMQRELHP TLLSSLEGIV DQMVWFRENW
HEEVLRQLQQ GLAKCYSVAF EKSGAVSDAK ITPHTLNFVK KLVSTFGVGL ENVSNVSTMF
SSAASESLAR RAQATAQDPV FQKLKGQFTT DFDFSVPGSM KLHNLISKLK KWIKILEAKT
KQLPKFFLIE EKCRFLSNFS AQTAEVEIPG EFLMPKPTHY YIKIARFMPR VEIVQKHNTA
ARRLYIRGHN GKIYPYLVMN DACLTESRRE ERVLQLLRLL NPCLEKRKET TKRHLFFTVP
RVVAVSPQMR LVEDNPSSLS LVEIYKQRCA KKGIEHDNPI SRYYDRLATV QARGTQASHQ
VLRDILKEVQ SNMVPRSMLK EWALHTFPNA TDYWTFRKMF TIQLALIGFA EFVLHLNRLN
PEMLQIAQDT GKLNVAYFRF DINDATGDLD ANRPVPFRLT PNISEFLTTI GVSGPLTASM
IAVARCFAQP NFKVDGILKT VLRDEIIAWH KKTQEDTSSP LSAAGQPENM DSQQLVSLVQ
KAVTAIMTRL HNLAQFEGGE SKVNTLVAAA NSLDNLCRMD PAWHPWL
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