ID Q59H09_HUMAN Unreviewed; 571 AA.
AC Q59H09;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Promyelocytic leukemia protein isoform 11 variant {ECO:0000313|EMBL:BAD92187.1};
DE Flags: Fragment;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92187.1};
RN [1] {ECO:0000313|EMBL:BAD92187.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Spleen {ECO:0000313|EMBL:BAD92187.1};
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RT "Homo sapiens protein coding cDNA.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB208950; BAD92187.1; -; mRNA.
DR AlphaFoldDB; Q59H09; -.
DR SMR; Q59H09; -.
DR PeptideAtlas; Q59H09; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19804; Bbox1_TRIM19_C-V; 1.
DR CDD; cd19770; Bbox2_TRIM19_C-V; 1.
DR CDD; cd16579; RING-HC_PML_C-V; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR021978; PML-like_CC.
DR InterPro; IPR047153; TRIM45/56/19.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25462; BONUS, ISOFORM C-RELATED; 1.
DR PANTHER; PTHR25462:SF301; PROTEIN PML; 1.
DR Pfam; PF12126; DUF3583; 2.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 60..95
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 127..169
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 187..225
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..45
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAD92187.1"
SQ SEQUENCE 571 AA; 63171 MW; CB1C256DED8C12A1 CRC64;
LGSMEPAPAR SPRPQQDPAR PQEPTMPPPE TPSEGRQPSP SPSPTERAPA SEEEFQFLRC
QQCQAEAKCP KLLPCLHTLC SGCLEASGMQ CPICQAPWPL GADTPALDNV FFESLQRRLS
VYRQIVDAQA VCTRCKESAD FWCFECEQLL CAKCFEAHQW FLKHEARPLA ELRNQSVREF
LDGTRKTNNI FCSNPNHRTP TLTSIYCRGC SKPLCCSCAL LDSSHSELKC DISAEIQQRQ
EELDAMTQAL QEQDSAFGAV HAQMHAAVGQ LGRARAETEE LIRERVRQVV AHVRAQEREL
LEAVDARYQR DYEEMASRLG RLDAVLQRIR TGSALVQRMK CYASDQEVLD MHGFLRQALC
RLRQEEPQSL QAAVRTDGFD EFKVRLQDLS SCITQGKDAA VSKKASPEAA STPRDPIDVD
LDVSNTTTAQ KRKCSQTQCP RKVIKMESEE GKEARLARSS PEQPRPSTSK AVSPPHLDGP
PSPRSPVIGS EVFLPNSNHV ASGAGEAGRE VGRAVAWVLP ARVWAVPLFC ILAPSRKPKA
NRSPLFPLNK IGKVHSVRGG ESGHSLPCVL P
//
