ID Q5ACW5_CANAL Unreviewed; 293 AA.
AC Q5ACW5;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=Casein kinase II subunit beta {ECO:0000256|RuleBase:RU361268};
DE Short=CK II beta {ECO:0000256|RuleBase:RU361268};
GN Name=CKB1 {ECO:0000313|CGD:CAL0000197149,
GN ECO:0000313|EMBL:AOW27084.1};
GN OrderedLocusNames=CAALFM_C200300CA {ECO:0000313|EMBL:AOW27084.1},
GN orf19.9650 {ECO:0000313|CGD:CAL0000197149};
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW27084.1, ECO:0000313|Proteomes:UP000000559};
RN [1] {ECO:0000313|EMBL:AOW27084.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2] {ECO:0000313|EMBL:AOW27084.1, ECO:0000313|Proteomes:UP000000559}
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3] {ECO:0000313|EMBL:AOW27084.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Regulatory subunit of casein kinase II/CK2 (By similarity).
CC As part of the kinase complex regulates the basal catalytic activity of
CC the alpha subunit a constitutively active serine/threonine-protein
CC kinase that phosphorylates a large number of substrates containing
CC acidic residues C-terminal to the phosphorylated serine or threonine.
CC {ECO:0000256|ARBA:ARBA00029397}.
CC -!- FUNCTION: Regulatory subunit of casein kinase II/CK2. As part of the
CC kinase complex regulates the basal catalytic activity of the alpha
CC subunit a constitutively active serine/threonine-protein kinase that
CC phosphorylates a large number of substrates containing acidic residues
CC C-terminal to the phosphorylated serine or threonine.
CC {ECO:0000256|RuleBase:RU361268}.
CC -!- SUBUNIT: Tetramer of two alpha and two beta subunits.
CC {ECO:0000256|RuleBase:RU361268}.
CC -!- SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
CC {ECO:0000256|ARBA:ARBA00006941, ECO:0000256|RuleBase:RU361268}.
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DR EMBL; CP017624; AOW27084.1; -; Genomic_DNA.
DR RefSeq; XP_719548.1; XM_714455.1.
DR AlphaFoldDB; Q5ACW5; -.
DR SMR; Q5ACW5; -.
DR STRING; 237561.Q5ACW5; -.
DR EnsemblFungi; C2_00300C_A-T; C2_00300C_A-T-p1; C2_00300C_A.
DR GeneID; 3638799; -.
DR KEGG; cal:CAALFM_C200300CA; -.
DR CGD; CAL0000197149; CKB1.
DR VEuPathDB; FungiDB:C2_00300C_A; -.
DR eggNOG; KOG3092; Eukaryota.
DR HOGENOM; CLU_034027_3_0_1; -.
DR InParanoid; Q5ACW5; -.
DR OMA; QNGSPMA; -.
DR OrthoDB; 5485421at2759; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0032545; C:CURI complex; IEA:EnsemblFungi.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005956; C:protein kinase CK2 complex; ISS:CGD.
DR GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR GO; GO:0034456; C:UTP-C complex; IBA:GO_Central.
DR GO; GO:0019887; F:protein kinase regulator activity; IDA:CGD.
DR GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:EnsemblFungi.
DR GO; GO:0006974; P:DNA damage response; IEA:EnsemblFungi.
DR GO; GO:0042790; P:nucleolar large rRNA transcription by RNA polymerase I; IEA:EnsemblFungi.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:EnsemblFungi.
DR GO; GO:0060962; P:regulation of ribosomal protein gene transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0006356; P:regulation of transcription by RNA polymerase I; IEA:EnsemblFungi.
DR GO; GO:0006359; P:regulation of transcription by RNA polymerase III; IBA:GO_Central.
DR Gene3D; 2.20.25.20; -; 1.
DR Gene3D; 1.10.1820.10; protein kinase ck2 holoenzyme, chain C, domain 1; 1.
DR InterPro; IPR016149; Casein_kin_II_reg-sub_N.
DR InterPro; IPR035991; Casein_kinase_II_beta-like.
DR InterPro; IPR000704; Casein_kinase_II_reg-sub.
DR PANTHER; PTHR11740; CASEIN KINASE II SUBUNIT BETA; 1.
DR PANTHER; PTHR11740:SF44; CASEIN KINASE II SUBUNIT BETA; 1.
DR Pfam; PF01214; CK_II_beta; 1.
DR PRINTS; PR00472; CASNKINASEII.
DR SMART; SM01085; CK_II_beta; 1.
DR SUPFAM; SSF57798; Casein kinase II beta subunit; 1.
DR PROSITE; PS01101; CK2_BETA; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000559}.
FT REGION 66..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 293 AA; 33750 MW; F490114DFA15622D CRC64;
MPSDPEEDYI PWIQQFCELF GHDYFVQVSQ DFIEDDFNLT GLSSQVPYYR EALYTILDYQ
VETAEDHNTD NTTTNTSNNN DSRNGTSKRN ASELPNKALL AHSAELLYGL IHARYIVSKQ
GLTAMASKFE RNDFGSCPRY FCDGMHLIPV GSTDVPGQET VRLFCPCCND IYIPSSSRYL
NIDGAFFGTT FPGLLVKMFP EIENQCRIRI TKFSQNDFGL KLFGFKINEL SATGPRMKWL
RMHPKTEDEK QEYDSCEYNV PISYLDEDEE MEEDDEEEDE VEEEDDDRTM ASE
//
