ID Q5ACY4_CANAL Unreviewed; 597 AA.
AC Q5ACY4;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 24-JAN-2024, entry version 130.
DE SubName: Full=Cdh1p {ECO:0000313|EMBL:AOW27099.1};
GN Name=CDH1 {ECO:0000313|CGD:CAL0000182223,
GN ECO:0000313|EMBL:AOW27099.1};
GN OrderedLocusNames=CAALFM_C200450CA {ECO:0000313|EMBL:AOW27099.1},
GN orf19.9631 {ECO:0000313|CGD:CAL0000182223};
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW27099.1, ECO:0000313|Proteomes:UP000000559};
RN [1] {ECO:0000313|EMBL:AOW27099.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2] {ECO:0000313|EMBL:AOW27099.1, ECO:0000313|Proteomes:UP000000559}
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3] {ECO:0000313|EMBL:AOW27099.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC {ECO:0000256|ARBA:ARBA00006445}.
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DR EMBL; CP017624; AOW27099.1; -; Genomic_DNA.
DR RefSeq; XP_719530.1; XM_714437.1.
DR AlphaFoldDB; Q5ACY4; -.
DR SMR; Q5ACY4; -.
DR STRING; 237561.Q5ACY4; -.
DR EnsemblFungi; C2_00450C_A-T; C2_00450C_A-T-p1; C2_00450C_A.
DR GeneID; 3638814; -.
DR KEGG; cal:CAALFM_C200450CA; -.
DR CGD; CAL0000182223; CDH1.
DR VEuPathDB; FungiDB:C2_00450C_A; -.
DR eggNOG; KOG0305; Eukaryota.
DR HOGENOM; CLU_014831_4_1_1; -.
DR InParanoid; Q5ACY4; -.
DR OMA; WSKNTDE; -.
DR OrthoDB; 20041at2759; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IBA:GO_Central.
DR GO; GO:1990757; F:ubiquitin ligase activator activity; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:1905786; P:positive regulation of anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0007096; P:regulation of exit from mitosis; IMP:CGD.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR PANTHER; PTHR19918:SF1; FIZZY-RELATED PROTEIN HOMOLOG; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000559};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 323..385
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 329..370
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 412..444
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 542..575
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 65953 MW; 17F4C76532314C56 CRC64;
MDKRDSNRPS KDNAIRNPFV SFETPRSPSR STRSLNPPKL NEMGAIQSSP PRRRNNNTIF
SDRYIPNRTG VDLQAAFSLT NEEILPDLRN TRNADNEIEI RREEEANRTF STVLKAELFG
DNVPMATANL SSATANSNLA NNRSKTGRTN TGIVNGASVS GAATSTSSLS TTPPRSSNSG
QNFPGSTGSS LPGNNNAIGN NDSHNIISAN ANNNISSDID DITSTPRRKT NLFTYQSPQK
SKPISRDLQQ ELYSLSPVRQ DSQKLLLSPQ KKPRTISKVP YRVLDAPELS DDFYLNLVDW
GQQDVLAVGL GDSVYLWDGA TQSVDRLCNL TNKDKVTSLN WIGTGTHLAI GTSKGLVEIW
DATRIKCIRT MTGHSLRVSS LAWNEHILSS GSRDRTILNR DVRIEDHFVN KFDNHKQEVC
GLKWNVEENK LASGGNDNNL FVWDGLNPKP LHQFTDHTAA VKAIAWSPHQ RGILASGGGT
ADKTIKTWNT LTGNLVHDVN TGSQVCNLIW SKNSNELVST HGYSRNQIIV WKYPSMQQIA
QLTGHTYRVL YLSLSPDGET IVTGAGDETL RFWNVFEKNR HNESPASVLL GAFSQLR
//
