ID Q5AW83_EMENI Unreviewed; 941 AA.
AC Q5AW83; C8VBC0;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 24-JAN-2024, entry version 120.
DE SubName: Full=mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070) {ECO:0000313|EMBL:CBF79397.1};
GN ORFNames=ANIA_07447 {ECO:0000313|EMBL:CBF79397.1};
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321 {ECO:0000313|EMBL:CBF79397.1, ECO:0000313|Proteomes:UP000000560};
RN [1] {ECO:0000313|Proteomes:UP000000560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC {ECO:0000313|Proteomes:UP000000560};
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.J., Wortman J.R., Batzoglou S.,
RA Lee S.I., Basturkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M., Hynes M., Paoletti M., Fischer R., Miller B.,
RA Dyer P., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2] {ECO:0000313|Proteomes:UP000000560}
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC {ECO:0000313|Proteomes:UP000000560};
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|ARBA:ARBA00011524}.
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DR EMBL; BN001304; CBF79397.1; -; Genomic_DNA.
DR RefSeq; XP_680716.1; XM_675624.1.
DR AlphaFoldDB; Q5AW83; -.
DR STRING; 227321.Q5AW83; -.
DR EnsemblFungi; CBF79397; CBF79397; ANIA_07447.
DR GeneID; 2869476; -.
DR KEGG; ani:AN7447.2; -.
DR VEuPathDB; FungiDB:AN7447; -.
DR eggNOG; KOG0495; Eukaryota.
DR HOGENOM; CLU_007010_0_0_1; -.
DR InParanoid; Q5AW83; -.
DR OMA; DGWAWYY; -.
DR OrthoDB; 655233at2759; -.
DR Proteomes; UP000000560; Chromosome IV.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:EnsemblFungi.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR010491; PRP1_N.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR PANTHER; PTHR11246:SF1; PRE-MRNA-PROCESSING FACTOR 6; 1.
DR Pfam; PF06424; PRP1_N; 1.
DR Pfam; PF13428; TPR_14; 2.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00386; HAT; 12.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 4.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW mRNA processing {ECO:0000256|ARBA:ARBA00023187};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000000560};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 13..177
FT /note="PRP1 splicing factor N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06424"
FT REPEAT 609..642
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 484..516
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 941 AA; 105523 MW; 0C28A8EB1EE477C9 CRC64;
MASGRKDFLS QPAPENYVAG LGRGATGFTT RSDLGPAREG PTPEQIQAAL AKRAQLLGAA
PPTAYGATRE KGKGEEKPAE EEDDERFQDP DNEVGLFAYG QFDQEDDEAD RIYREVDEKM
DRRRKARREA RERQEREEYE RKNPKIQQQF VDLKRSLASV SEDEWANLPE VGDLTGRNRR
TKQNLRMQQR FYAVPDSVLA SARDSSQFDT TVADDGTATD AGANGADGMI TNFANISAAR
DKVLQVKLDQ AAMGSSGDAA SGSATSIDPK GYLTSLTQSE LKAGEIEVGD VKRVRVLLES
VTRTNPKHAP GWIALARLEE LAGRIVTARN VIAKGCELCP KSEDAWLENI RLNEGHNAKV
IAANAIKNND HSTRLWIEAM RLETEPRAKK NVLRQAILHI PQSVTIWKEA VNLEEDPADA
RLLLAKAVEL IPLSVELWLA LARLETPENA QKVLNAARKA VPTSHEIWIA ASRLQEQMGT
FNKVNVMKRA VQSLARENAM LKREEWIAEA EKCEEEGAVL TCGAIIRETL GWGLDEDDDR
KDIWMDDAKA SISRGKYETA RAIYAYALRV FVNRRSIWVA AADLERNHGT KEALWQVLEK
AVEACPQSEE LWLQLAKEKW QSGEIDDARR VLGRAFNQNP NNEDIWLAAV KLEADAQQTD
QARELLATAR REAGTDRVWI KSVAFERQLG NVDDALDLVN QGLQLYPKAD KLWMMKGQIY
ESQNKLPQAR EAYGTGTRAC PKSVALWLLA SRLEEKAGAV VRARSVLDRA RLAVPNSPEL
WTESVRVERR ANNIPQAKVL MARALQEVPS SGLLWSESIW HLEPRSQRKA RSLEAIKKVD
NDPILFITVA RIFWGERRLE KAMTWFEKAI ISNSDFGDAW AWYYKFLLQH GTDEKRADVI
SKCVLSEPKH GEVWQSIAKN PANAYKSTED ILKLVADSLV Q
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