ID PRP46_EMENI Reviewed; 452 AA.
AC Q5BE22; C8VST3;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=Pre-mRNA-splicing factor prp46;
DE AltName: Full=Pre-mRNA-processing protein 46;
GN Name=prp46; ORFNames=AN1208;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Involved in pre-mRNA splicing and required for cell cycle
CC progression at G2/M. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.
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DR EMBL; AACD01000017; EAA65801.1; -; Genomic_DNA.
DR EMBL; BN001308; CBF87932.1; -; Genomic_DNA.
DR RefSeq; XP_658812.1; XM_653720.1.
DR AlphaFoldDB; Q5BE22; -.
DR SMR; Q5BE22; -.
DR STRING; 227321.Q5BE22; -.
DR EnsemblFungi; CBF87932; CBF87932; ANIA_01208.
DR GeneID; 2876986; -.
DR KEGG; ani:AN1208.2; -.
DR VEuPathDB; FungiDB:AN1208; -.
DR eggNOG; KOG0285; Eukaryota.
DR HOGENOM; CLU_000288_72_2_1; -.
DR InParanoid; Q5BE22; -.
DR OMA; FAMCFDQ; -.
DR OrthoDB; 118158at2759; -.
DR Proteomes; UP000000560; Chromosome VIII.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR045241; Prp46/PLRG1-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19923:SF0; PLEIOTROPIC REGULATOR 1; 1.
DR PANTHER; PTHR19923; WD40 REPEAT PROTEINPRL1/PRL2-RELATED; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Repeat; Spliceosome; WD repeat.
FT CHAIN 1..452
FT /note="Pre-mRNA-splicing factor prp46"
FT /id="PRO_0000051165"
FT REPEAT 141..180
FT /note="WD 1"
FT REPEAT 183..222
FT /note="WD 2"
FT REPEAT 225..264
FT /note="WD 3"
FT REPEAT 267..308
FT /note="WD 4"
FT REPEAT 310..349
FT /note="WD 5"
FT REPEAT 350..388
FT /note="WD 6"
FT REPEAT 399..438
FT /note="WD 7"
FT REGION 61..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 49302 MW; 7900CB74E0E270AA CRC64;
MDVIPSTTPG EAVRISAKRT AELFGPEYLM VTPSASNGSI GVSYRRKTEY EHVKELPPAL
AAKQAQAAAA RSKRPKISSR SEGSGSGDKS GASTALVRRG GRASGAAGDD KPTSLIQRPS
ATRQQPPEWH APWKLMRVIS GHLGWVRSLA VEPNNEWFAS GAGDRTIKIW NLATGALRLT
LTGHISTVRG LAVSPRHPYL FSCGEDKMVK CWDLETNKVI RHYHGHLSGV YTLALHPRLD
LLVTGGRDGV ARVWDMRTRS NIHVLSGHTG TVADVQCQEA DPQVITGSLD ATVRLWDLAA
GKTMGVLTHH KKGIRSLATH PREFTFASAS TGSIKQWKCP GGEFMQNFEG HNAIINTLSV
NEDNVLFSGG DNGSMSFWDW KTGYRYQTID TTAQPGSLEA EAGIMTSTFD RTGLRLITGE
ADKTIKVWKQ DDQATPETHP VTWAPTLGRQ RY
//
