ID Q5BQA0_HUMAN Unreviewed; 75 AA.
AC Q5BQA0;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=Kallikrein 4 {ECO:0000313|EMBL:AAX30051.1};
DE EC=3.4.21.- {ECO:0000313|EMBL:AAX30051.1};
DE SubName: Full=Kallikrein related peptidase 4 {ECO:0000313|Ensembl:ENSP00000472091.1};
GN Name=KLK4 {ECO:0000313|EMBL:AAX30051.1,
GN ECO:0000313|Ensembl:ENSP00000472091.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAX30051.1};
RN [1] {ECO:0000313|EMBL:AAX30051.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Prostate {ECO:0000313|EMBL:AAX30051.1};
RX PubMed=11124349; DOI=10.1016/S0009-9120(00)00178-8;
RA Obiezu C.V., Diamandis E.P.;
RT "An alternatively spliced variant of KLK4 expressed in prostatic tissue.";
RL Clin. Biochem. 33:599-600(2000).
RN [2] {ECO:0000313|Ensembl:ENSP00000472091.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3] {ECO:0000313|EMBL:AAX30051.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Prostate {ECO:0000313|EMBL:AAX30051.1};
RA Obiezu C.V., Diamandis E.P.;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSP00000472091.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC011483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY923170; AAX30051.1; -; mRNA.
DR RefSeq; NP_001289890.1; NM_001302961.1.
DR MEROPS; S01.251; -.
DR DNASU; 9622; -.
DR Ensembl; ENST00000602148.1; ENSP00000472091.1; ENSG00000167749.12.
DR GeneID; 9622; -.
DR UCSC; uc061bup.1; human.
DR CTD; 9622; -.
DR HGNC; HGNC:6365; KLK4.
DR VEuPathDB; HostDB:ENSG00000167749; -.
DR GeneTree; ENSGT01020000230389; -.
DR HOGENOM; CLU_163459_3_0_1; -.
DR OrthoDB; 4629979at2759; -.
DR BioGRID-ORCS; 9622; 9 hits in 1146 CRISPR screens.
DR ChiTaRS; KLK4; human.
DR GenomeRNAi; 9622; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000167749; Expressed in prostate gland and 125 other cell types or tissues.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR24271:SF65; KALLIKREIN-4; 1.
DR PANTHER; PTHR24271; KALLIKREIN-RELATED; 1.
DR Pfam; PF00089; Trypsin; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000313|EMBL:AAX30051.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..75
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014105534"
FT DOMAIN 31..75
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 75 AA; 8047 MW; CEC848B8408EDE19 CRC64;
MATAGNPWGW FLGYLILGVA GSLVSGSCSQ IINGEDCSPH SQPWQAALVM ENELFCSGVL
VHPQWVLSAA HCFQK
//
