ID Q5CQB6_CRYPI Unreviewed; 686 AA.
AC Q5CQB6;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=cgd4_1360 {ECO:0000313|EMBL:EAK87615.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK87615.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK87615.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK87615.1}.
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DR EMBL; AAEE01000009; EAK87615.1; -; Genomic_DNA.
DR RefSeq; XP_625732.1; XM_625732.1.
DR AlphaFoldDB; Q5CQB6; -.
DR STRING; 353152.Q5CQB6; -.
DR EnsemblProtists; EAK87615; EAK87615; cgd4_1360.
DR GeneID; 3372642; -.
DR KEGG; cpv:cgd4_1360; -.
DR VEuPathDB; CryptoDB:cgd4_1360; -.
DR InParanoid; Q5CQB6; -.
DR OMA; EIKMLCR; -.
DR OrthoDB; 5471056at2759; -.
DR Proteomes; UP000006726; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR CDD; cd16649; mRING-HC-C3HC5_CGRF1-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045194; MGRN1/RNF157-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22996; MAHOGUNIN; 1.
DR PANTHER; PTHR22996:SF0; RING-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 635..672
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 160..217
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 686 AA; 79275 MW; 64A0FC436BD809E3 CRC64;
MEDISIIECS KLYPALCFDL YGSPGFHNIY VGLLVIISGI WLVSRLAKIV EFYEMIRIIQ
EEGKVINIPS LGPYSNDLKK LIKSHISQII RERCSISPIN VKKLQVMNIM EESTLKTRLI
PNSSSSSSPD ESYSLEVSFK VDSFVPHSIQ LFWGVDYFAA KELLIEERKV ENELNTISNK
MSRRMALGSS ISMFDQLKLK EKNNENLEEN KIEKNTNIGL EYNNNVNNST RLFENMEIDH
DEKERTDLNV PFDFSPSESM KSLANINPIL YTTEISNRRY YNYFGNSHDR DYFDYHTNMS
RRGIFNIGPR ITRIVLKIKQ ILRDNIVVNT ISNSLNYSTW NSSLLGNNAI ILSRSIKRLF
ENAFFYNTIS NINNNNNNNN NNNNINLGGF SLTKSSLLSS ASVTTELLLD KYHYDQLKSK
SGSNNKYNID LKKIINQPST NLDEIKYQIL INKLNPMYIT EKKYYEKGLS QDYSEKIKLT
PEYLTSCNLN SPYYDTQEQE INSKDEHQVL NHGDYYEIQD KCNHKEIFWN SDIINFNKNN
IDSSILKIKT ENEENKEMPR IPLLILIRAN IGVIEDESIL TNNIIAINFD LIQDHYNIPY
LMYKPIILKQ AISNSHGILI EPYDTYGLED DELDCLICMS NPKDVILLPC RHCISCESCL
RSLRQDKCPL CRTTFSGFVV LPIKNS
//
